Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 6/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 3/20 | 0.35 |
| ▸ | TLK2 | Q86UE8 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6780227 | 0.87 | RET (0.36) | RETPAK1TLK2 | |
| SCHEMBL6330913 | 0.86 | RET (0.37) | RETPAK1TLK2GSK3B | |
| SCHEMBL6330542 | 0.82 | RET (0.42) | RETPAK1TLK2GSK3BNOX4 | |
| SCHEMBL6332445 | 0.81 | PAK1 (0.39) | RETPAK1KDRFLT3MAPK1 | |
| SCHEMBL6328460 | 0.81 | PAK1 (0.37) | RETPAK1TLK2 | |
| SCHEMBL6774320 | 0.80 | RET (0.36) | RETPAK1TLK2 | |
| SCHEMBL6331144 | 0.77 | RET (0.55) | RETTLK2GSK3BNOX4FLT4 | |
| SCHEMBL6329200 | 0.77 | ACHE (0.45) | RET | |
| SCHEMBL6336940 | 0.77 | ACHE (0.45) | RET | |
| SCHEMBL6330656 | 0.76 | RET (0.46) | RETTLK2GSK3BNOX4FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009898-A1 | New substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-01-13 | — | — | US | disclosed |
| US-6794395-B1 | Substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009898-A1 | New substituted indolinones, their manufacture and their use as medicaments | CCNE1, CDK1, CCNI | RET 154/4885PAK1 532/4885TLK2 1364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.