Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 5/20 | 0.53 |
| ▸ | HTR3A | P46098 | 1/20 | 0.50 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.50 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1792057 | 0.92 | NPC1 (0.48) | CHRNA7HTR3ACHRNB4CHRNA3NPC1 | |
| SCHEMBL928212 | 0.84 | CHRNA7 (0.54) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| SCHEMBL927781 | 0.84 | CHRNA7 (0.72) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| SCHEMBL1792137 | 0.84 | CHRNA7 (0.72) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| SCHEMBL928716 | 0.84 | CHRNA7 (0.72) | CHRNA7HTR3ACHRNB4CHRNA3 | |
| SCHEMBL1791919 | 0.83 | CHRNA7 (0.54) | CHRNA7HTR3ACHRNB4CHRNA3NPC1 | |
| SCHEMBL1796875 | 0.83 | CHRNA7 (0.54) | CHRNA7HTR3ACHRNB4CHRNA3NPC1 | |
| SCHEMBL1793416 | 0.83 | CHRNA7 (0.47) | CHRNA7HTR3ACHRNB4CHRNA3NPC1 | |
| SCHEMBL1795776 | 0.82 | CHRNA7 (0.56) | CHRNA7HTR3ACHRNB4CHRNA3NPC1 | |
| SCHEMBL1794434 | 0.81 | CHRNA7 (0.50) | CHRNA7HTR3ACHRNB4CHRNA3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065178-A1 | Substituted diazabicycloakane derivatives | ABBOTT LABORATORIES | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065178-A1 | Substituted diazabicycloakane derivatives | CHRNA7, CHRNA1, CHRNA5 | CHRNA7 1/4885HTR3A 160/4885CHRNB4 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.