Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.53 |
| ▸ | DRD3 | P35462 | 9/20 | 0.53 |
| ▸ | DRD2 | P14416 | 8/20 | 0.53 |
| ▸ | PARP1 | P09874 | 3/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20424472 | 0.86 | DRD4 (0.55) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL6329420 | 0.84 | DRD4 (0.50) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL8195715 | 0.81 | PARP1 (0.60) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL9437792 | 0.81 | DRD4 (0.53) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL9437789 | 0.81 | DRD4 (0.53) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL10642401 | 0.81 | PARP1 (0.60) | DRD4DRD3DRD2PARP1NR3C2 | |
| SCHEMBL3777130 | 0.81 | DRD4 (0.55) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL8191537 | 0.78 | DRD4 (0.55) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL2056366 | 0.78 | PARP1 (0.77) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL6717655 | 0.77 | DRD4 (0.50) | DRD4DRD3DRD2PARP1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050209274-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | ABOTT LABORATORIES | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209274-A1 | Antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor | MCHR1, MCHR2, MC1R | DRD4 397/4885DRD3 336/4885DRD2 216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.