Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.53 |
| ▸ | DRD3 | P35462 | 9/20 | 0.53 |
| ▸ | DRD2 | P14416 | 8/20 | 0.53 |
| ▸ | PARP1 | P09874 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.51 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | HTR1D | P28221 | 1/20 | 0.45 |
| ▸ | HTR1B | P28222 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9437898 | 0.88 | PARP1 (0.68) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL8191537 | 0.88 | DRD4 (0.55) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL8195715 | 0.85 | PARP1 (0.60) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL9437789 | 0.85 | DRD4 (0.53) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL3777130 | 0.81 | DRD4 (0.55) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL2056366 | 0.81 | PARP1 (0.77) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL6329957 | 0.81 | DRD4 (0.53) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL276741 | 0.79 | MMP12 (0.51) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL29512901 | 0.79 | MMP12 (0.51) | DRD4DRD3DRD2PARP1HTR1A | |
| SCHEMBL27590225 | 0.78 | TP53 (0.47) | DRD4DRD3DRD2PARP1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5296477-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | disclosed |
| US-5225409-A | Serotoninergic disorders; anxiolytic agents; schizophrenia | ADIR ET COMPAGNIE (FR) | 1993-07-06 | — | — | US | disclosed |
| US-5196434-A | Antidepressants, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1993-03-23 | — | — | US | disclosed |