Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | AR | P10275 | 9/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326508 | 0.87 | POLB (0.75) | POLBARPARP1PRMT5SMN1; SMN2 | |
| SCHEMBL6323602 | 0.81 | POLB (0.65) | POLBARPARP1PRMT5SMN1; SMN2 | |
| SCHEMBL11412658 | 0.79 | POLB (1.00) | POLBARPARP1PRMT5SMN1; SMN2 | |
| SCHEMBL5163309 | 0.74 | POLB (0.72) | POLBARPARP1PRMT5SMN1; SMN2 | |
| SCHEMBL7462930 | 0.74 | PRMT5 (0.68) | POLBARPARP1PRMT5SMN1; SMN2 | |
| SCHEMBL30231202 | 0.74 | PRMT5 (0.68) | POLBARPARP1PRMT5SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6279576 | 0.73 | POLB (0.70) | POLBARPARP1PRMT5SMN1; SMN2 | |
| SCHEMBL21575767 | 0.71 | PRMT5 (0.64) | POLBARPARP1PRMT5SMN1; SMN2 | |
| SCHEMBL23909125 | 0.71 | PRMT5 (0.68) | POLBARPARP1PRMT5SMN1; SMN2 | |
| SCHEMBL29404780 | 0.71 | PRMT5 (0.68) | POLBARPARP1PRMT5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924284-B2 | PARP inhibitors | ICOS CORPORATION (US) | 2005-08-02 | — | — | US | disclosed |