Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Apc-100. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.50 |
| ▸ | TTPA | P49638 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.49 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Apc-100 SCHEMBL3134545 | 0.92 | CYP3A4 (0.60) | CYP3A4TSHRPTGS1PTGS2CYP1A2 | |
| SCHEMBL5772272 | 0.84 | CYP3A4 (0.48) | CYP3A4TSHRPTGS1PTGS2CYP1A2 | |
| SCHEMBL5796964 | 0.84 | CYP3A4 (0.48) | CYP3A4TSHRPTGS1PTGS2CYP1A2 | |
| SCHEMBL5796169 | 0.84 | CYP3A4 (0.48) | CYP3A4TSHRPTGS1PTGS2CYP1A2 | |
| SCHEMBL1285831 | 0.84 | CYP3A4 (0.48) | CYP3A4TSHRPTGS1PTGS2CYP1A2 | |
| SCHEMBL5774935 | 0.84 | CYP3A4 (0.48) | CYP3A4TSHRPTGS1PTGS2CYP1A2 | |
| SCHEMBL8259133 | 0.84 | PTGS1 (0.45) | CYP3A4TSHRPTGS1PTGS2CYP1A2 | |
| SCHEMBL4427867 | 0.84 | CYP3A4 (0.62) | CYP3A4TSHRPTGS1PTGS2CYP1A2 | |
| SCHEMBL4472285 | 0.83 | CYP3A4 (0.61) | CYP3A4TSHRPTGS1PTGS2CYP1A2 | |
| SCHEMBL14283910 | 0.83 | CYP3A4 (0.47) | CYP3A4TSHRPTGS1PTGS2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 6011 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122080172-A | T cell receptor engineering transformation method and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| US-12630606-B2 | Peptide deficient-MHC class I/chaperone compositions and methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-05-19 | — | — | US | claimed |
| CN-122067592-A | Method for screening candidate CTL epitopes based on binding free energy calculation | 大连大学 | 2026-05-19 | — | — | CN | claimed |
| CN-122070133-A | Pharmaceutical compositions containing androgen receptor inhibitors/antagonists, methods and uses | 苏州开拓药业股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| EP-4740019-A1 | A METHOD OF IDENTIFYING MHC-BINDING PROTEINS AND INTERACTING PEPTIDES IN A SAMPLE | Immatics Biotechnologies GmbH (DE) | 2026-05-13 | — | — | EP | claimed |
| EP-4739395-A2 | BISPECIFIC POLYPEPTIDE MOLECULE | Enara Bio Limited (GB) | 2026-05-13 | — | — | EP | claimed |
| CN-122029198-A | Method for purifying small multi-domain proteins | 英美偌科有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-20260126421-A1 | METHOD OF DETERMINING AN AMOUNT OF WATER IN A SAMPLE USING A PHENOL COMPOUND | HONEYWELL INTERNATIONAL INC. (US) | 2026-05-07 | — | — | US | claimed |
| US-20260126450-A1 | LIBRARY-SCALE METHODS FOR POLYPEPTIDE FUNCTIONAL ANALYSIS | MASSACHUSETTS INST OF TECHNOLOGY (US) | 2026-05-07 | — | — | US | claimed |
| US-20260109786-A1 | CHEMICALLY CONTROLLED MONOCLONAL ANTIBODY TARGET ENGAGEMENT | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2026-04-23 | — | — | US | claimed |
| EP-1727780-A1 | PROCESS FOR PREPARING (METH)ACRYLIC ESTERS. | BASF AKTIENGESELLSCHAFT (DE) | 2006-12-06 | — | — | EP | claimed |
| US-20060105030-A1 | Transdermal therapeutic system | AXXONIS PHARMA AG (DE) | 2006-05-18 | — | — | US | claimed |
| WO-2005082828-A1 | METHOD FOR THE PRODUCTION OF (METH)ACRYLIC ACID ESTERS | BASF AKTIENGESELLSCHAFT (DE) | 2005-09-09 | — | — | WO | claimed |
| EP-1336602-A1 | Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases | Scaramuzzino, Giovanni (IT) | 2003-08-20 | — | — | EP | claimed |
| US-6605667-B1 | 1,1-disubstituted ethylene monomers such as alpha-cyano-acrylates; storage stability | CLOSURE MEDICAL CORPORATION | 2003-08-12 | — | — | US | claimed |
| WO-2002020069-A2 | ANTIOXIDANT ENRICHED ADHESIVE COMPOSITIONS AND STORAGE CONTAINERS THEREFOR | CLOSURE MEDICAL CORPORATION (US) | 2002-03-14 | — | — | WO | claimed |
| WO-1998034646-A2 | TARGETED ANTIOXIDANTS | UNIVERSITY OF HERTFORDSHIRE (GB) | 1998-08-13 | — | — | WO | claimed |
| EP-0566718-A1 | STABILIZERS FOR PLASTIC MATERIALS | Ciba SC Holding AG (CH) | 1993-10-27 | — | — | EP | claimed |
| WO-1993010175-A1 | STABILIZERS FOR PLASTIC MATERIALS | F. HOFFMANN-LA ROCHE AG (CH) | 1993-05-27 | — | — | WO | claimed |
| EP-0445735-A1 | Melanogenesis-inhibiting endermic preparation | Sansho Seiyaku Co., Ltd. (JP) | 1991-09-11 | — | — | EP | claimed |