Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 11/20 | 0.49 |
| ▸ | HTR2B | P41595 | 5/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL196337 | 0.83 | — | — | |
| SCHEMBL184451 | 0.79 | ADRA1A (0.55) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL1494449 | 0.79 | — | — | |
| SCHEMBL1133528 | 0.78 | ADRA1A (0.53) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL7856564 | 0.78 | ADRA1A (0.53) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL724530 | 0.78 | ADRA1A (0.53) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL4585762 | 0.76 | ADRA1A (0.52) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL7809418 | 0.76 | ADRA1A (0.52) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL1299321 | 0.76 | ADRA1A (0.52) | ADRA1AHTR2BADRA2AADRA1DADRA1B | |
| SCHEMBL2488698 | 0.76 | ADRA1A (0.52) | ADRA1AHTR2BADRA2AADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419418-A1 | 4-AZETIDINYL-1-HETEROATOM LINKED-CYCLOHEXANE ANTAGONISTS OF CCR2 | Janssen Pharmaceutica, N.V. (BE) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010121036-A1 | 4-AZETIDINYL-1-HETEROATOM LINKED-CYCLOHEXANE ANTAGONISTS OF CCR2 | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-21 | — | — | WO | disclosed |
| EP-1583535-A4 | METHODS FOR TREATING DIABETES | SCIOS INC (US) | 2008-03-19 | — | — | EP | disclosed |
| EP-1583535-A2 | METHODS FOR TREATING DIABETES | SCIOS INC. (US) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004053107-A2 | METHODS FOR TREATING DIABETES | SCIOS INC. (US) | 2004-06-24 | — | — | WO | disclosed |