SCHEMBL633484

SCHEMBL633484

CC1(C)[C@H]2C[C@H](C/C=C\CCCC(=O)O)[C@@H](NC(=O)c3csc4ccccc34)[C@@H]1C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PTGDR Q13258 20/20 1.00
TBXA2R P21731 6/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12923819 0.92 PTGDR (0.85) PTGDRTBXA2R
SCHEMBL18269299 0.92 PTGDR (0.85) PTGDRTBXA2R
SCHEMBL14514981 0.92 PTGDR (0.84) PTGDRTBXA2R
SCHEMBL6935578 0.90 PTGDR (1.00) PTGDRTBXA2R
SCHEMBL633588 0.90 PTGDR (1.00) PTGDRTBXA2R
SCHEMBL6150895 0.90 PTGDR (1.00) PTGDRTBXA2R
SCHEMBL1224329 0.90 PTGDR (1.00) PTGDRTBXA2R
SCHEMBL6936201 0.90 PTGDR (1.00) PTGDRTBXA2R
SCHEMBL6936207 0.90 PTGDR (1.00) PTGDRTBXA2R
SCHEMBL5176774 0.85 PTGDR (0.74) PTGDRTBXA2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050222235-A1 Drugs for improving the prognosis of brain injury and a method of screening the same SHIONOGI & CO., LTD. (JP) 2005-10-06 US claimed
EP-1535629-A1 DRUGS FOR IMPROVING THE PROGNOSIS OF BRAIN INJURY AND A METHOD OF SCREENING THE SAME Japan Science and Technology Agency (JP) 2005-06-01 EP claimed
US-8568967-B2 Method for diagnosis of severity and prediction of recurrence in eosinophilic inflammatory disease TAIHO PHARMACEUTICAL CO., LTD. (JP) 2013-10-29 US disclosed
EP-1882937-B1 METHOD FOR DIAGNOSIS OF SEVERITY AND PREDICTION OF RECURRENCE IN EOSINOPHILIC INFLAMMATORY DISEASE TAIHO PHARMACEUTICAL CO LTD (JP) 2012-02-22 EP disclosed
US-20100138937-A1 Method for diagnosis of severity and prediction of recurrence in eosinophilic inflammatory disease AROS ELECTRONICS AB (SE) 2010-06-03 US disclosed
EP-1882937-A1 METHOD FOR DIAGNOSIS OF SEVERITY AND PREDICTION OF RECURRENCE IN EOSINOPHILIC INFLAMMATORY DISEASE TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) 2008-01-30 EP disclosed
EP-1598065-A2 Drugs for improving prognosis of brain injury Japan Science and Technology Agency (JP) 2005-11-23 EP disclosed
US-20050227984-A1 Drugs for improving the prognosis of brain injury and a method of screening the same TAIHO PHARMACEUTICAL CO., LTD. (JP) 2005-10-13 US disclosed
US-20050222235-A1 Drugs for improving the prognosis of brain injury and a method of screening the same SHIONOGI & CO., LTD. (JP) 2005-10-06 US disclosed
EP-1535629-A1 DRUGS FOR IMPROVING THE PROGNOSIS OF BRAIN INJURY AND A METHOD OF SCREENING THE SAME Japan Science and Technology Agency (JP) 2005-06-01 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050222235-A1 Drugs for improving the prognosis of brain injury and a method of screening the same HPGDS, PTGDR, PTGDR2 PTGDR 2/4885TBXA2R 34/4885
US-20050227984-A1 Drugs for improving the prognosis of brain injury and a method of screening the same HPGDS, PTGDR, PTGDR2 PTGDR 2/4885TBXA2R 34/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.