Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.69 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.60 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.60 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3596386 | 0.86 | KDR (0.72) | KDRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6332010 | 0.86 | KDR (0.72) | KDRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL22103768 | 0.85 | KDR (0.57) | KDRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6279216 | 0.83 | CNR1 (0.62) | KDRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3651635 | 0.82 | KDR (1.00) | KDRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL3602543 | 0.82 | VCP (0.58) | KDRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4601039 | 0.81 | MEN1 (0.54) | KDRMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6330357 | 0.81 | KDR (0.65) | KDRALDH1A1GAASMN1; SMN2MEN1 | |
| SCHEMBL6330228 | 0.81 | KDR (0.65) | KDRALDH1A1GAASMN1; SMN2MEN1 | |
| SCHEMBL5633679 | 0.80 | MAPK13 (0.87) | MAPK13MAPK12MAPK11MAPK14ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050228031-A1 | Tyrosine kinase inhibitors | BILODEAU MARK T | 2005-10-13 | — | — | US | claimed |
| US-20050228031-A1 | Tyrosine kinase inhibitors | BILODEAU MARK T | 2005-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050228031-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | KDR 5/4885MAPK13 175/4885MAPK12 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.