⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842350 | 0.71 | — | — | |
| SCHEMBL7801798 | 0.62 | — | — | |
| SCHEMBL20474 | 0.62 | — | — | |
| SCHEMBL194859 | 0.62 | — | — | |
| SCHEMBL144134 | 0.59 | — | — | |
| SCHEMBL6050070 | 0.59 | — | — | |
| SCHEMBL1323234 | 0.59 | — | — | |
| SCHEMBL16868590 | 0.59 | — | — | |
| SCHEMBL3405180 | 0.59 | — | — | |
| SCHEMBL2403785 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900216-B2 | Dihydroimidazo[2,1-b]thiazole and dihydro-5h-thiazolo[3,2-A]pyrimidines as antidepressant agents | KNOLL GMBH (DE) | 2005-05-31 | — | — | US | disclosed |
| US-20030166628-A1 | Dihydroimidazo[2,1-b]thiazole and dihydro-5h-thiazolo[3,2-A]pyrimidines as antidepressant agents | KNOLL GMBH (DE) | 2003-09-04 | — | — | US | disclosed |
| EP-1268489-A1 | DIHYDROIMIDAZO[2,1-B]THIAZOLE AND DIHYDRO-5H-THIAZOLO[3,2-A]PYRIMIDINES AS ANTIDEPRESSANT AGENTS | Knoll GmbH (DE) | 2003-01-02 | — | — | EP | disclosed |
| WO-2002026747-A1 | DIHYDROIMIDAZO[2,1-B]THIAZOLE AND DIHYDRO-5H-THIAZOLO[3,2-A]PYRIMIDINE DERIVATIVES WITH 5-HT RECEPTOR AFFINITY | KNOLL GMBH (DE) | 2002-04-04 | — | — | WO | disclosed |
| EP-1178993-A1 | THIAZOLODERIATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Knoll GmbH (DE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2001068653-A1 | DIHYDROIMIDAZO[2,1-B]THIAZOLE AND DIHYDRO-5H-THIAZOLO[3,2-A]PYRIMIDINES AS ANTIDEPRESSANT AGENTS | KNOLL GMBH (DE) | 2001-09-20 | — | — | WO | disclosed |
| WO-2000071549-A1 | THIAZOLODERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KNOLL GMBH (DE) | 2000-11-30 | — | — | WO | disclosed |