Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 6/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6331060 | 0.89 | KMT2A (0.43) | RETMEN1KMT2ABRD4NPC1 | |
| SCHEMBL6331528 | 0.89 | MEN1 (0.43) | RETMEN1KMT2ABRD4NPC1 | |
| SCHEMBL6337818 | 0.89 | KMT2A (0.44) | RETMEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL6331388 | 0.86 | PSEN1 (0.40) | RETMEN1KMT2ABRD4TLK2 | |
| SCHEMBL6337046 | 0.86 | RET (0.39) | RETMEN1KMT2ABRD4TLK2 | |
| SCHEMBL6329112 | 0.84 | RET (0.39) | RETMEN1KMT2ABRD4TLK2 | |
| SCHEMBL7474241 | 0.84 | RET (0.42) | RETMEN1KMT2AHCRTR2BRD4 | |
| SCHEMBL6339064 | 0.84 | BRD4 (0.40) | RETMEN1KMT2ABRD4TLK2 | |
| SCHEMBL6335856 | 0.83 | RET (0.39) | RETMEN1KMT2ABRD4TLK2 | |
| SCHEMBL6330822 | 0.82 | RET (0.44) | RETBRD4TLK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009898-A1 | New substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2005-01-13 | — | — | US | disclosed |
| US-6794395-B1 | Substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009898-A1 | New substituted indolinones, their manufacture and their use as medicaments | CCNE1, CDK1, CCNI | RET 154/4885MEN1 1645/4885KMT2A 1678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.