Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6338477 | 0.84 | RET (0.42) | RETMEN1KMT2ABRD4HCRTR2 | |
| SCHEMBL6338475 | 0.79 | MEN1 (0.43) | RETMEN1KMT2AHCRTR2NPC1 | |
| SCHEMBL6338481 | 0.79 | MEN1 (0.43) | RETMEN1KMT2AHCRTR2NPC1 | |
| SCHEMBL7475417 | 0.78 | RET (0.44) | RETBRD4TLK2GSK3B | |
| SCHEMBL7473364 | 0.78 | RET (0.47) | RETKMT2ABRD4ALDH1A1LMNA | |
| SCHEMBL7476129 | 0.77 | RET (0.43) | RETBRD4TLK2GSK3B | |
| SCHEMBL7476920 | 0.77 | RET (0.45) | RETBRD4TLK2GSK3B | |
| SCHEMBL7472918 | 0.77 | RET (0.54) | RETBRD4TLK2GSK3B | |
| SCHEMBL5782382 | 0.77 | RET (0.43) | RETMEN1KMT2AHCRTR2NPC1 | |
| SCHEMBL5782386 | 0.77 | RET (0.43) | RETMEN1KMT2AHCRTR2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212318-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-06-12 | — | — | EP | disclosed |
| WO-2001016130-A1 | SUBSTITUTED INDOLINONES AS TYROSINE KINASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-03-08 | — | — | WO | disclosed |