Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 3/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10493368 | 0.91 | KDM4E (0.36) | KDM4ECYP3A4CA1CA2 | |
| SCHEMBL79143 | 0.91 | — | — | |
| Hydrogen Sulfide SCHEMBL27533982 | 0.86 | — | — | |
| SCHEMBL31134117 | 0.86 | — | — | |
| Ethane SCHEMBL28343509 | 0.86 | — | — | |
| Water SCHEMBL28754572 | 0.86 | — | — | |
| Fluoride SCHEMBL5159140 | 0.86 | — | — | |
| Methane SCHEMBL9153389 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL27552935 | 0.86 | — | — | |
| Ethylene SCHEMBL29216386 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8198497-B2 | Oligomerization catalyst; zirconium tetrachloride diphenylsulfone; zirconium tetrachloride diethylsulfone | POLIMERI EUROPA S.P.A. (IT) | 2012-06-12 | — | — | US | disclosed |
| US-20050070425-A1 | Catalytic composition and process for the selective oligomerization of ethylene to light linear alpha-olefins | POLIMERI EUROPA S.P.A (IT) | 2005-03-31 | — | — | US | disclosed |
| EP-1453604-A2 | CATALYTIC COMPOSITION AND PROCESS FOR THE SELECTIVE OLIGOMERIZATION OF ETHYLENE TO LIGHT LINEAR ALPHA-OLEFINS | Polimeri Europa S.r.l. (IT) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003053573-A2 | CATALYTIC COMPOSITION AND PROCESS FOR THE SELECTIVE OLIGOMERIZATION OF ETHYLENE TO LIGHT LINEAR ALPHA-OLEFINS | POLIMERI EUROPA S.P.A. (IT) | 2003-07-03 | — | — | WO | disclosed |