SCHEMBL6340707

SCHEMBL6340707

COC(=O)c1ccccc1NC(=O)Cc1ccc(Oc2ccc(O)cc2)cc1

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.61
ALDH1A1 P00352 8/20 0.57
MAPK10 P53779 4/20 0.55
KDM4E B2RXH2 4/20 0.55
HSD17B10 Q99714 3/20 0.55
TSHR P16473 1/20 0.55
MAPK8 P45983 2/20 0.54
MAPK9 P45984 2/20 0.54
SMN1; SMN2 Q16637 1/20 0.53
GAA P10253 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
KCNQ2 O43526 1/20 0.51
HTT P42858 2/20 0.50
TP53 P04637 1/20 0.50
MEN1 O00255 1/20 0.49
POLB P06746 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6337230 0.91 KMT2A (0.53) KMT2AALDH1A1MAPK10KDM4EHSD17B10
SCHEMBL8039717 0.88 KMT2A (0.56) KMT2AALDH1A1MAPK10KDM4EHSD17B10
SCHEMBL6349020 0.88 ALDH1A1 (0.60) KMT2AALDH1A1MAPK10KDM4EHSD17B10
SCHEMBL8037895 0.88 ALDH1A1 (0.64) KMT2AALDH1A1MAPK10KDM4EHSD17B10
SCHEMBL8037864 0.87 SMN1; SMN2 (0.58) KMT2AALDH1A1MAPK10KDM4EHSD17B10
SCHEMBL6337014 0.87 ALDH1A1 (0.66) KMT2AALDH1A1MAPK10KDM4EHSD17B10
SCHEMBL8044298 0.87 ALDH1A1 (0.60) KMT2AALDH1A1KDM4ESMN1; SMN2GAA
SCHEMBL6341406 0.86 KMT2A (0.51) KMT2AALDH1A1MAPK10KDM4EHSD17B10
SCHEMBL8037875 0.86 ALDH1A1 (0.54) KMT2AALDH1A1MAPK10KDM4EHSD17B10
SCHEMBL8044170 0.86 ALDH1A1 (0.55) KMT2AALDH1A1MAPK10KDM4EHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1245380-C Anthranilic acid derivatives TEIJIN LTD (JP) 2006-03-15 CN disclosed
US-6890932-B2 Immunoglobulin e antibody suppressors TEIJIN LIMITED (JP) 2005-05-10 US disclosed
US-20050027008-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredient TEIJIN LIMITED 2005-02-03 US disclosed
EP-1101755-B1 ANTHRANILIC ACID DERIVATIVES TEIJIN LTD (JP) 2004-10-06 EP disclosed
US-20030232811-A1 Immunoglobulin e antibody suppressors TEIJIN LIMITED 2003-12-18 US disclosed
US-20030220402-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredients TEIJIN LIMITED (JP) 2003-11-27 US disclosed
US-6649656-B1 Anticarcinogenic, antiallergen, antishock, and antiasthmatic agents TEIJIN LIMITED (JP) 2003-11-18 US disclosed
EP-1256341-A1 CANCER REMEDY COMPRISING ANTHRANILIC ACID DERIVATIVE AS ACTIVE INGREDIENT TEIJIN LIMITED (JP) 2002-11-13 EP disclosed
CN-1319086-A Anthranilic acid derivatives TEIJIN LTD (JP) 2001-10-24 CN disclosed
EP-1101755-A1 ANTHRANILIC ACID DERIVATIVES TEIJIN LIMITED (JP) 2001-05-23 EP disclosed
EP-0806412-B1 BENZENE DERIVATIVES TEIJIN LTD (JP) 2000-04-05 EP disclosed
US-5808144-A ANTIALLERGENS TEIJIN LIMITED (JP) 1998-09-15 US disclosed
EP-0806412-A1 BENZENE DERIVATIVES TEIJIN LIMITED (JP) 1997-11-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030220402-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredients HCCS, BCOR, CBR1 KMT2A 553/4885ALDH1A1 1126/4885MAPK10 648/4885
US-20050027008-A1 Cancer remedy comprising anthranilic acid derivatives as active ingredient CA9, HCCS, CA7 KMT2A 799/4885ALDH1A1 1389/4885MAPK10 221/4885
US-20030232811-A1 Immunoglobulin e antibody suppressors IGLV6-57, FCGRT, IGSF11 KMT2A 1762/4885ALDH1A1 250/4885MAPK10 1714/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.