Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ELANE | P08246 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KLK7 | P49862 | 6/20 | 0.48 |
| ▸ | KLK14 | Q9P0G3 | 6/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 6/20 | 0.48 |
| ▸ | CTSG | P08311 | 5/20 | 0.48 |
| ▸ | CTRC | Q99895 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | C1R | P00736 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11710939 | 0.76 | KDM4E (0.54) | KDM4EKMT2ASMN1; SMN2LMNAELANE | |
| SCHEMBL6349049 | 0.76 | ELANE (0.59) | KDM4EKMT2ALMNAPOLBELANE | |
| SCHEMBL6339961 | 0.76 | KDM4E (0.46) | KDM4EKMT2ASMN1; SMN2HSD17B10ELANE | |
| SCHEMBL7098826 | 0.76 | KDM4E (0.79) | KDM4EKMT2ASMN1; SMN2HSD17B10LMNA | |
| SCHEMBL6350945 | 0.75 | C1R (0.46) | KDM4ELMNAELANEALDH1A1C1R | |
| SCHEMBL12360274 | 0.74 | KDM4E (0.65) | KDM4EKMT2ASMN1; SMN2HSD17B10LMNA | |
| SCHEMBL6341584 | 0.74 | ELANE (0.44) | KDM4EKMT2ASMN1; SMN2POLBELANE | |
| SCHEMBL5370167 | 0.74 | ELANE (0.68) | KMT2AELANEMEN1C1R | |
| SCHEMBL10657011 | 0.71 | ELANE (0.68) | KDM4EKMT2ASMN1; SMN2HSD17B10POLB | |
| SCHEMBL22952908 | 0.71 | KLK7 (0.67) | KDM4EKMT2ASMN1; SMN2HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6949648-B2 | Condensed pyrazole derivatives, process for producing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-09-27 | — | — | US | disclosed |
| US-20030187014-A1 | Condensed pyrazole derivatives, process for producing the same and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-10-02 | — | — | US | disclosed |
| EP-1270572-A1 | CONDENSED PYRAZOLE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030187014-A1 | Condensed pyrazole derivatives, process for producing the same and use thereof | PTGS1, PTGIS, IL5 | KDM4E 1741/4885KMT2A 3347/4885SMN1; SMN2 4864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.