Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 1/20 | 0.72 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 2/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | LAP3 | P28838 | 3/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.43 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6343386 | 0.90 | CSNK1E (0.60) | CSNK1ERENLAP3ANPEPRNPEP | |
| SCHEMBL4516038 | 0.90 | CSNK1E (0.88) | CSNK1ETRPA1RENSLC6A2TAAR1 | |
| SCHEMBL27648870 | 0.90 | CSNK1E (0.88) | CSNK1ETRPA1RENSLC6A2TAAR1 | |
| SCHEMBL4508560 | 0.90 | CSNK1E (0.88) | CSNK1ETRPA1RENSLC6A2TAAR1 | |
| SCHEMBL6350695 | 0.85 | CSNK1E (0.56) | CSNK1ESLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL3651529 | 0.81 | CSNK1E (0.63) | CSNK1ETRPA1SIGMAR1CNR2CTSL | |
| SCHEMBL11590730 | 0.80 | CSNK1E (0.76) | CSNK1ETRPA1SLC6A2TAAR1MAOA | |
| SCHEMBL6344357 | 0.79 | CSNK1E (0.50) | CSNK1ESLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL6626575 | 0.79 | CSNK1E (0.50) | CSNK1ESLC6A2TAAR1MAOASLC6A4 | |
| SCHEMBL6626581 | 0.79 | CSNK1E (0.50) | CSNK1ESLC6A2TAAR1MAOASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6906104-B2 | Aminediols for the treatment of Alzheimer's disease | PHARMACIA & UPJOHN COMPANY (US) | 2005-06-14 | — | — | US | disclosed |
| US-20030092747-A1 | Aminediols for the treatment of Alzheimer's disease | PHARMACIA & UPJOHN COMPANY | 2003-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030092747-A1 | Aminediols for the treatment of Alzheimer's disease | BACE1, APP, BACE2 | CSNK1E 1341/4885TRPA1 4545/4885REN 2055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.