Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE1A | P54750 | 8/20 | 0.43 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.43 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.43 |
| ▸ | PDE2A | O00408 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CFTR | P13569 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | SCN1A | P35498 | 1/20 | 0.41 |
| ▸ | PDE6C | P51160 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19759435 | 0.84 | PDE1A (0.46) | PDE1APDE1BPDE1CPDE2AALDH1A1 | |
| SCHEMBL7857649 | 0.82 | PDE1A (0.43) | PDE1APDE1BPDE1CPDE2AALDH1A1 | |
| SCHEMBL7006341 | 0.82 | PDE1A (0.43) | PDE1APDE1BPDE1CPDE2AALDH1A1 | |
| SCHEMBL7014557 | 0.81 | PDE1A (0.42) | PDE1APDE1BPDE1CPDE2AALDH1A1 | |
| SCHEMBL5864895 | 0.77 | PDE3B (0.47) | CYP3A4PDE3BPDE3ASLC16A1 | |
| SCHEMBL7010765 | 0.76 | SLC16A1 (0.38) | PDE1APDE1BPDE1CPDE2AALDH1A1 | |
| SCHEMBL5864669 | 0.76 | PDE1B (0.47) | PDE1APDE1BPDE1CPDE2ATSHR | |
| SCHEMBL5865238 | 0.76 | SMN1; SMN2 (0.43) | PDE1APDE1BPDE1CPDE2AALDH1A1 | |
| SCHEMBL5864833 | 0.76 | SLC16A1 (0.39) | PDE1APDE1BPDE1CPDE2ATSHR | |
| SCHEMBL7007286 | 0.75 | PDE1B (0.38) | PDE1APDE1BPDE1CPDE2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890923-B2 | Compounds | ASTRAZENECA AB (SE) | 2005-05-10 | — | — | US | disclosed |
| US-20040122028-A1 | Novel compounds | ASTRAZENECA AB (SE) | 2004-06-24 | — | — | US | disclosed |
| US-20040014634-A1 | Thieno[2,3-d]pyrimidinediones and their use as pharmaceuticals | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | US | disclosed |
| EP-1107973-B1 | NOVEL THIENO[2,3-d]PYRIMIDINEDIONES, PROCESS FOR THEIR PREPARATION AND USE THEREOF IN THERAPY | ASTRAZENECA AB (SE) | 2003-11-05 | — | — | EP | disclosed |
| US-6300334-B1 | DRUGS FOR TREATMENT OF RESPIRATORY SYSTEM DISORDERS | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |
| EP-1107973-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012514-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014634-A1 | Thieno[2,3-d]pyrimidinediones and their use as pharmaceuticals | DPYD, TYMP, TYMS | PDE1A 2691/4885PDE1B 1866/4885PDE1C 3163/4885 |
| US-20040122028-A1 | Novel compounds | DPYD, TYMS, TYMP | PDE1A 3225/4885PDE1B 2268/4885PDE1C 3535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.