Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PDE8B | O95263 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6348716 | 0.99 | ATM (0.43) | ATMHSD17B10PDE8BSMN1; SMN2ALDH1A1 | |
| SCHEMBL6345733 | 0.94 | ATM (0.44) | ATMHSD17B10PDE8BSMN1; SMN2ALDH1A1 | |
| SCHEMBL3815408 | 0.94 | ATM (0.44) | ATMHSD17B10PDE8BSMN1; SMN2ALDH1A1 | |
| SCHEMBL16012113 | 0.90 | PDE8B (0.46) | ATMHSD17B10PDE8BSMN1; SMN2ALDH1A1 | |
| SCHEMBL1427736 | 0.89 | HSD17B10 (0.46) | ATMHSD17B10PDE8BSMN1; SMN2ALDH1A1 | |
| SCHEMBL86228 | 0.89 | HSD17B10 (0.46) | ATMHSD17B10PDE8BSMN1; SMN2ALDH1A1 | |
| SCHEMBL1061613 | 0.89 | HSD17B10 (0.46) | ATMHSD17B10PDE8BSMN1; SMN2ALDH1A1 | |
| SCHEMBL29036991 | 0.88 | ATM (0.48) | ATMHSD17B10PDE8BSMN1; SMN2ALDH1A1 | |
| SCHEMBL6338610 | 0.88 | ATM (0.43) | ATMHSD17B10PDE8BSMN1; SMN2ALDH1A1 | |
| SCHEMBL31072006 | 0.85 | ATM (0.42) | ATMHSD17B10PDE8BSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6878736-B1 | Histamine H3 receptor ligands | JAMES BLACK FOUNDATION LIMITED (GB) | 2005-04-12 | — | — | US | disclosed |
| EP-1056733-B1 | HISTAMINE H3 RECEPTOR LIGANDS | BLACK JAMES FOUNDATION (GB) | 2004-01-07 | — | — | EP | disclosed |