Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 9/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | ULK1 | O75385 | 2/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6174182 | 0.88 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL6173768 | 0.82 | CRHR1 (0.47) | CRHR1 | |
| SCHEMBL6342774 | 0.78 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL6167996 | 0.78 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL6172799 | 0.77 | CRHR1 (0.50) | CRHR1 | |
| SCHEMBL6167691 | 0.77 | CRHR1 (0.65) | CRHR1 | |
| SCHEMBL6347154 | 0.76 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL6346265 | 0.76 | CRHR1 (0.48) | CRHR1 | |
| SCHEMBL6345711 | 0.76 | CRHR1 (0.53) | CRHR1 | |
| SCHEMBL6351576 | 0.76 | CRHR1 (0.53) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6964965-B2 | Substituted pyrazine derivatives | PHARMACIA & UPJOHN (US) | 2005-11-15 | — | — | US | claimed |