Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29139900 | 0.68 | TSHR (0.39) | KDM4EGAAHPGDALDH1A1POLB | |
| SCHEMBL14077595 | 0.63 | KDM4E (0.39) | KDM4EGAAHPGDALDH1A1POLB | |
| SCHEMBL29664746 | 0.62 | TSHR (0.37) | KDM4EGAAHPGDALDH1A1POLB | |
| SCHEMBL12064685 | 0.62 | TSHR (0.37) | KDM4EGAAHPGDALDH1A1POLB | |
| SCHEMBL3503403 | 0.62 | KDM4E (0.45) | KDM4EGAAHPGDALDH1A1POLB | |
| SCHEMBL18658877 | 0.62 | TSHR (0.40) | KDM4EHPGDALDH1A1L3MBTL1LMNA | |
| SCHEMBL14003785 | 0.61 | TSHR (0.36) | KDM4EGAAHPGDALDH1A1HSD17B10 | |
| SCHEMBL19631305 | 0.61 | HPGD (0.38) | KDM4EGAAHPGDALDH1A1POLB | |
| SCHEMBL20322329 | 0.61 | KDM4E (0.43) | KDM4EGAAHPGDALDH1A1POLB | |
| SCHEMBL21648147 | 0.61 | ALDH1A1 (0.41) | KDM4EGAAHPGDALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6936602-B1 | Benzazepine derivatives, process for the preparation of the same and uses thereof | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2005-08-30 | — | — | US | disclosed |
| EP-1186604-A1 | BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF | Takeda Chemical Industries, Ltd. (JP) | 2002-03-13 | — | — | EP | disclosed |