Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 17/20 | 1.00 |
| ▸ | ESR1 | P03372 | 3/20 | 0.67 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6351573 | 1.00 | PTGS2 (1.00) | PTGS2ESR1ESR2 | |
| SCHEMBL6342283 | 0.91 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL3248532 | 0.90 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL3244795 | 0.90 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL6342907 | 0.90 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL6354448 | 0.90 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL8304225 | 0.88 | PTGS2 (0.78) | PTGS2 | |
| SCHEMBL6341317 | 0.88 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL6351545 | 0.86 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL27432266 | 0.86 | PTGS2 (0.76) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960611-B2 | Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof | INSTITUTE OF MATERIA MEDICA (CN) | 2005-11-01 | — | — | US | disclosed |
| US-20040058977-A1 | Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof | INSTITUTE OF MATERIA MEDIC, CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058977-A1 | Sulfonyl-containing 2,3-diarylindole compounds, methods for making same, and methods of use thereof | PTGS2, PTGES2, PTGER2 | PTGS2 1/4885ESR1 3049/4885ESR2 487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.