Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.33 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6351240 | 1.00 | APP (0.38) | APPADORA2AADORA2BADORA1POLB | |
| SCHEMBL3994275 | 0.81 | CYP2C9 (0.54) | POLBKDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL3994272 | 0.81 | CYP2C9 (0.54) | POLBKDM4EALDH1A1MAPTKMT2A | |
| SCHEMBL6112138 | 0.76 | ADORA2A (0.34) | APPADORA2AADORA2BADORA1POLB | |
| SCHEMBL6112142 | 0.76 | ADORA2A (0.34) | APPADORA2AADORA2BADORA1POLB | |
| SCHEMBL7474650 | 0.75 | — | — | |
| SCHEMBL18655709 | 0.75 | — | — | |
| SCHEMBL7618854 | 0.75 | — | — | |
| SCHEMBL19421181 | 0.74 | MEN1 (0.42) | ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL18959125 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050096354-A1 | Process for the preparation of substituted aryl pyrazoles | PFIZER, INC. (US) | 2005-05-05 | — | — | US | disclosed |
| WO-2005023773-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED ARYL PYRAZOLES | PFIZER LIMITED (GB) | 2005-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050096354-A1 | Process for the preparation of substituted aryl pyrazoles | CYP3A5, DDT, CYP3A4 | APP 1430/4885ADORA2A 3836/4885ADORA2B 3508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.