Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | EED | O75530 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.45 |
| ▸ | CBR1 | P16152 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29361626 | 0.85 | MAOA (0.46) | RECQLMEN1SLC22A2SLC22A1EED | |
| SCHEMBL6345040 | 0.85 | MAOA (0.46) | RECQLMEN1SLC22A2SLC22A1EED | |
| SCHEMBL6946660 | 0.83 | MAOA (0.45) | RECQLMEN1SLC22A2SLC22A1EED | |
| SCHEMBL31086523 | 0.83 | MAOA (0.45) | RECQLMEN1SLC22A2SLC22A1EED | |
| SCHEMBL29769302 | 0.82 | MEN1 (0.42) | RECQLMEN1SLC22A2SLC22A1EED | |
| SCHEMBL3398957 | 0.82 | MEN1 (0.42) | RECQLMEN1SLC22A2SLC22A1EED | |
| SCHEMBL6945838 | 0.80 | MAOA (0.42) | RECQLMEN1SLC22A2SLC22A1EED | |
| SCHEMBL8051275 | 0.80 | MAOA (0.42) | RECQLMEN1SLC22A2SLC22A1EED | |
| Diaporthin SCHEMBL30553770 | 0.80 | MAOA (0.42) | RECQLMEN1SLC22A2SLC22A1EED | |
| Diaporthin SCHEMBL29058565 | 0.80 | MAOA (0.42) | RECQLMEN1SLC22A2SLC22A1EED |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900239-B2 | Tumor chemopotentiation using isocoumarin derivatives | ILWZ ILEX PRODUCTS, INC. (US) | 2005-05-31 | — | — | US | disclosed |
| US-6589981-B2 | Combination treatment with ionizing radiation and/or chemotherapy | ILEX ONCOLOGY, INC. | 2003-07-08 | — | — | US | disclosed |
| EP-0930310-B1 | ISOCOUMARIN DERIVATIVES AND USE THEREOF IN DRUGS | MERCIAN CORP (JP) | 2003-03-26 | — | — | EP | disclosed |
| US-20020165210-A1 | Tumor chemopotentiation using isocoumarin derivatives | GENZYME CORPORATION | 2002-11-07 | — | — | US | disclosed |
| US-20020019366-A1 | Tumor radiosensitization and/or chemopotentiation using isocoumarin derivatives | GLBC LLC | 2002-02-14 | — | — | US | disclosed |
| US-6020363-A | IMMUNOLOGY MODERATORS, ANTICANCER AGENTS | MERCIAN CORPORATION (JP) | 2000-02-01 | — | — | US | disclosed |
| EP-0930310-A1 | ISOCOUMARIN DERIVATIVES AND USE THEREOF IN DRUGS | MERCIAN CORPORATION (JP) | 1999-07-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019366-A1 | Tumor radiosensitization and/or chemopotentiation using isocoumarin derivatives | HCCS, IDH2, IDH3A | RECQL 1625/4885MEN1 1166/4885SLC22A2 2592/4885 |
| US-20020165210-A1 | Tumor chemopotentiation using isocoumarin derivatives | MCL1, IDH2, MYADM | RECQL 3855/4885MEN1 1491/4885SLC22A2 1095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.