Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | GALR2 | O43603 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | XBP1 | P17861 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10487709 | 0.84 | POLB (0.48) | ALDH1A1LMNARAB9ANPSR1L3MBTL1 | |
| SCHEMBL8075327 | 0.81 | PDGFRB (0.62) | ALDH1A1LMNARAB9ANPSR1POLB | |
| SCHEMBL6348564 | 0.76 | TSHR (0.51) | RAB9AL3MBTL1POLBPDGFRBFGFR1 | |
| SCHEMBL10487618 | 0.76 | ESR1 (0.55) | ALDH1A1LMNARAB9ANPSR1L3MBTL1 | |
| SCHEMBL20594337 | 0.76 | PDGFRB (0.58) | ALDH1A1LMNARAB9APOLBPDGFRB | |
| SCHEMBL28654992 | 0.74 | ALDH1A1 (0.50) | ALDH1A1LMNARAB9ANPSR1POLB | |
| SCHEMBL10487718 | 0.73 | POLB (0.57) | ALDH1A1LMNARAB9ANPSR1POLB | |
| SCHEMBL10605429 | 0.73 | ALDH1A1 (0.46) | ALDH1A1LMNARAB9ANPSR1L3MBTL1 | |
| SCHEMBL10487611 | 0.73 | POLB (0.46) | ALDH1A1LMNARAB9ANPSR1L3MBTL1 | |
| SCHEMBL1928460 | 0.73 | ALDH1A1 (0.68) | ALDH1A1LMNARAB9ANPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050090498-A1 | 3-Quinolin-2(1h)-ylideneindolin-2-one derivative | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2005-04-28 | — | — | US | disclosed |
| CN-1511151-A | 3-quinoline-2-(1H)-ylideneindolin-2-one derivatives | ֮����ҩ��ʽ���� | 2004-07-07 | — | — | CN | disclosed |
| EP-1396490-A1 | 3-QUINOLINE-2-(1H)-YLIDENEINDOLIN-2-ONE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 2004-03-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050090498-A1 | 3-Quinolin-2(1h)-ylideneindolin-2-one derivative | KDR, FLT4, FLT1 | ALDH1A1 1986/4885LMNA 4317/4885RAB9A 1706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.