Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.91 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.91 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.91 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.50 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL3505988 | 1.00 | — | — | |
| Glycine SCHEMBL433424 | 1.00 | — | — | |
| Glycine SCHEMBL1555637 | 1.00 | GLRA1 (0.91) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL28861283 | 1.00 | GLRA1 (0.91) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL11056979 | 1.00 | GLRA1 (0.91) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL37746 | 1.00 | — | — | |
| Glycine SCHEMBL5053459 | 1.00 | — | — | |
| Glycine SCHEMBL1650224 | 1.00 | GLRA1 (0.91) | GLRA1SLC6A9OR51E2GABRR1BLM | |
| Glycine SCHEMBL3941221 | 0.96 | — | — | |
| Glycine SCHEMBL2163120 | 0.96 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030113282-A1 | Low residue anhydrous antiperspirant stick composition | CHURCH & DWIGHT CO., INC. | 2003-06-19 | — | — | US | claimed |
| EP-1464329-B1 | Process for stabilizing antiperspirant actives | COLGATE PALMOLIVE CO (US) | 2012-05-30 | — | — | EP | disclosed |
| EP-1027031-B1 | A process for stabilizing an aluminum zirconium composition | COLGATE PALMOLIVE CO (US) | 2005-08-24 | — | — | EP | disclosed |
| EP-1464329-A2 | Antiperspirant actives and formulations made therefrom | Colgate-Palmolive Company (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-0889720-B1 | LOW RESIDUE ANTIPERSPIRANT STICK COMPOSITION | COLGATE PALMOLIVE CO (US) | 2004-08-18 | — | — | EP | disclosed |
| US-20030113282-A1 | Low residue anhydrous antiperspirant stick composition | CHURCH & DWIGHT CO., INC. | 2003-06-19 | — | — | US | disclosed |
| US-6066314-A | AQUEOUS SOLUTIONS OF ALUMINUM ZIRCONIUM GLYCINE SALTS; SILOXANE POLYAMIDE GELLING AGENT; D4, D5 AND D6 CYCLOMETHICONES; AMINO ACID SELECTED FROM THE GROUP CONSISTING OF GLYCINE, ALANINE, THREONINE AND LEUCINE | COLGATE-PALMOLIVE COMPANY (US) | 2000-05-23 | — | — | US | disclosed |
| US-5997850-A | STABILIZED ALUMINUM ZIRCONIUM COMPOSITION HAVING AN AQUEOUS COMPONENT AND FORMED WITH A WATER SOLUBLE AMINO ACID IN AN AMOUNT IN THE RANGE OF 1:1.2-1:5 OF ZIRCONIUM:AMINO ACID ON A WEIGHT:WEIGHT BASIS. | COLGATE-PALMOLIVE COMPANY (US) | 1999-12-07 | — | — | US | disclosed |
| US-5972319-A | EXHIBITING LESS VISIBLE COMPRISING: GELLING AGENT, SOLVENT, NON-VOLATILE EMMOLLIENT, COSMETICALLY ACTIVE DEODORANT AND/OR ANTIPERSPIRANT, SURFACTANT | THE COLGATE-PALMOLIVE COMPANY (US) | 1999-10-26 | — | — | US | disclosed |
| US-5833964-A | NO NOTICABLE WHITE RESIDUE; ACTIVE INGREDIENT, GELLING AGENT, EMOLLIENT WITH REFRACTIVE INDEX OF AT LEAST 1.4460 | COLGATE-PALMOLIVE COMPANY (US) | 1998-11-10 | — | — | US | disclosed |
| US-5531986-A | MIXTURE OF SILICONE, WAX, DIMETHICONE AND ANTIPERSPIRANT ACTIVE MATERIAL | THE MENNEN COMPANY (US) | 1996-07-02 | — | — | US | disclosed |