Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | PPARG | P37231 | 10/20 | 0.51 |
| ▸ | PPARA | Q07869 | 10/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | LAP3 | P28838 | 1/20 | 0.46 |
| ▸ | ALPI | P09923 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5812524 | 1.00 | SLC6A4 (0.53) | SLC6A4PPARGPPARASLC6A2SLC6A3 | |
| SCHEMBL540925 | 0.87 | SLC6A4 (0.52) | SLC6A4PPARGPPARASLC6A2SLC6A3 | |
| SCHEMBL7962713 | 0.86 | SLC6A2 (0.52) | SLC6A4PPARGPPARASLC6A2SLC6A3 | |
| SCHEMBL11413099 | 0.85 | SLC7A5 (0.46) | SLC7A5LTA4HLAP3ALPIPKM | |
| SCHEMBL11129132 | 0.85 | SLC7A5 (0.65) | SLC6A2SLC7A5LTA4HLAP3ALPI | |
| SCHEMBL5812189 | 0.85 | SLC7A5 (0.65) | SLC6A2SLC7A5LTA4HLAP3ALPI | |
| SCHEMBL5807631 | 0.85 | SLC7A5 (0.65) | SLC6A2SLC7A5LTA4HLAP3ALPI | |
| SCHEMBL7698421 | 0.85 | ALPI (0.62) | SLC7A5LTA4HLAP3ALPIPKM | |
| SCHEMBL2029167 | 0.85 | ALPI (0.62) | SLC7A5LTA4HLAP3ALPIPKM | |
| SCHEMBL7415433 | 0.85 | ALPI (0.62) | SLC7A5LTA4HLAP3ALPIPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960575-B2 | For use as inhibitors of chymase | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2005-11-01 | — | — | US | disclosed |
| US-6713472-B1 | 2-OXO-1,2,3,4-TETRAHYDROPYRAZINE DERIVATIVES; CHYMASE INHIBITORS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2004-03-30 | — | — | US | disclosed |