Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS11D | O60235 | 11/20 | 0.53 |
| ▸ | F2 | P00734 | 9/20 | 0.53 |
| ▸ | F10 | P00742 | 8/20 | 0.53 |
| ▸ | PLG | P00747 | 7/20 | 0.53 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.46 |
| ▸ | F11 | P03951 | 1/20 | 0.46 |
| ▸ | TMPRSS2 | O15393 | 2/20 | 0.46 |
| ▸ | PROC | P04070 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.41 |
| ▸ | TMPRSS6 | Q8IU80 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3752985 | 0.92 | TMPRSS11D (0.51) | TMPRSS11DF2F10PLGKLKB1 | |
| SCHEMBL2167189 | 0.92 | TMPRSS11D (0.50) | TMPRSS11DF2F10PLGKLKB1 | |
| SCHEMBL2167674 | 0.91 | TMPRSS11D (0.53) | TMPRSS11DF2F10PLGKLKB1 | |
| SCHEMBL12847292 | 0.88 | F2 (0.58) | TMPRSS11DF2F10PLGKLKB1 | |
| SCHEMBL2167336 | 0.87 | TMPRSS11D (0.51) | TMPRSS11DF2F10PLGKLKB1 | |
| Hydrochloric Acid SCHEMBL6853389 | 0.86 | TMPRSS11D (0.50) | TMPRSS11DF2F10PLGTMPRSS2 | |
| SCHEMBL5493824 | 0.83 | PLG (0.44) | TMPRSS11DF2F10PLGTMPRSS2 | |
| SCHEMBL12514178 | 0.82 | F2 (0.56) | TMPRSS11DF2F10PLGKLKB1 | |
| Hydrochloric Acid SCHEMBL309506 | 0.82 | PLG (0.43) | TMPRSS11DF2F10PLGTMPRSS2 | |
| SCHEMBL17366096 | 0.81 | F2 (0.57) | TMPRSS11DF2F10PLGKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2420255-A2 | Polypeptide inhibitors of urokinase type plasminogen activator | Ecole Polytechnique Federale De Lausanne (EPFL) (CH) | 2012-02-22 | — | — | EP | disclosed |