Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 3/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 4/20 | 0.36 |
| ▸ | KIF11 | P52732 | 4/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3197354 | 1.00 | HSD17B2 (0.48) | HSD17B2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3197345 | 1.00 | HSD17B2 (0.48) | HSD17B2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL8996389 | 0.90 | HSD17B2 (0.45) | HSD17B2CHRNB2CHRNA4KIF11CETP | |
| SCHEMBL6272668 | 0.90 | HSD17B2 (0.44) | HSD17B2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5969111 | 0.90 | HSD17B2 (0.44) | HSD17B2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5969109 | 0.90 | HSD17B2 (0.44) | HSD17B2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1176456 | 0.87 | HSD17B2 (0.42) | HSD17B2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1176450 | 0.87 | HSD17B2 (0.42) | HSD17B2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1054468 | 0.87 | HSD17B2 (0.42) | HSD17B2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL1176452 | 0.87 | HSD17B2 (0.42) | HSD17B2CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245570-A1 | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines | DENINNO MICHAEL P | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245570-A1 | 4-carboxyamino-2-substituted-1,2,3,4-tetrahydroquinolines | CETP, APOB, HDLBP | HSD17B2 1814/4885CHRNB2 3694/4885CHRNA4 3406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.