Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 7/20 | 0.48 |
| ▸ | HTR2A known ✓ | P28223 | 4/20 | 0.48 |
| ▸ | HTR2B known ✓ | P41595 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 3/20 | 0.42 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6364123 | 1.00 | HTR2C (0.48) | HTR2CHTR2AHTR2BDYRK1ASLC22A12 | |
| Fumaric Acid SCHEMBL5678109 | 1.00 | HTR2C (0.48) | HTR2CHTR2AHTR2BDYRK1ASLC22A12 | |
| Fumaric Acid SCHEMBL5678095 | 1.00 | HTR2C (0.48) | HTR2CHTR2AHTR2BDYRK1ASLC22A12 | |
| Fumaric Acid SCHEMBL7098346 | 0.90 | HTR2C (0.40) | HTR2CHTR2AHTR2BDYRK1ASLC22A12 | |
| Fumaric Acid SCHEMBL7098345 | 0.90 | HTR2C (0.40) | HTR2CHTR2AHTR2BDYRK1ASLC22A12 | |
| SCHEMBL905840 | 0.89 | HTR2C (0.58) | HTR2CHTR2AHTR2BDYRK1ASLC22A12 | |
| Fumaric Acid SCHEMBL4845619 | 0.85 | HTR2A (0.47) | HTR2CHTR2AHTR2BSLC22A12KMO | |
| SCHEMBL4845615 | 0.85 | SLC22A12 (0.42) | HTR2CHTR2AHTR2BSLC22A12KMO | |
| Fumaric Acid SCHEMBL4845606 | 0.85 | HTR2A (0.47) | HTR2CHTR2AHTR2BSLC22A12KMO | |
| Fumaric Acid SCHEMBL5678103 | 0.82 | DYRK1A (0.49) | HTR2CHTR2ADYRK1ASLC22A12KMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956036-B1 | 6-hydroxy-indazole derivatives for treating glaucoma | ALCON, INC. (CH) | 2005-10-18 | — | — | US | disclosed |
| EP-1268438-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | Alcon, Inc (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070702-A1 | 6-HYDROXY-INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |