Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 13/20 | 0.58 |
| ▸ | HTR2C known ✓ | P28335 | 13/20 | 0.58 |
| ▸ | HTR2B known ✓ | P41595 | 7/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.55 |
| ▸ | KMO | O15229 | 4/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6364134 | 1.00 | HTR2A (0.58) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| SCHEMBL6361132 | 0.84 | HTR2A (0.51) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| Fumaric Acid SCHEMBL7994290 | 0.81 | HTR2C (0.48) | HTR2AHTR2CHTR2BCA2 | |
| Fumaric Acid SCHEMBL7994287 | 0.81 | HTR2C (0.48) | HTR2AHTR2CHTR2BCA2 | |
| Fumaric Acid SCHEMBL8001761 | 0.81 | HTR2C (0.48) | HTR2AHTR2CHTR2BCA2 | |
| Fumaric Acid SCHEMBL7994292 | 0.81 | HTR2C (0.48) | HTR2AHTR2CHTR2BCA2 | |
| Fumaric Acid SCHEMBL8001767 | 0.81 | HTR2C (0.48) | HTR2AHTR2CHTR2BCA2 | |
| Fumaric Acid SCHEMBL8006854 | 0.78 | HTR2A (0.58) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| Fumaric Acid SCHEMBL8009273 | 0.78 | HTR2A (0.58) | HTR2AHTR2CHTR2BHTR1AADRA2A | |
| Fumaric Acid SCHEMBL8009278 | 0.78 | HTR2A (0.58) | HTR2AHTR2CHTR2BHTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956036-B1 | 6-hydroxy-indazole derivatives for treating glaucoma | ALCON, INC. (CH) | 2005-10-18 | — | — | US | disclosed |