Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13388545 | 0.90 | MAPT (0.43) | MAPTSCN8ASCN10AHCRTR1HCRTR2 | |
| SCHEMBL6959867 | 0.86 | MAPT (0.37) | MAPTHCRTR1HCRTR2PTGDR2ERAP1 | |
| SCHEMBL6258541 | 0.85 | SCN8A (0.40) | MAPTSCN8ASCN10AHCRTR1HCRTR2 | |
| SCHEMBL13388895 | 0.85 | MAPT (0.43) | MAPTHCRTR1HCRTR2PTGDR2 | |
| SCHEMBL6249040 | 0.83 | RAF1 (0.43) | MAPT | |
| SCHEMBL5596997 | 0.82 | MAPT (0.43) | MAPTHCRTR1HCRTR2PTGDR2ERAP1 | |
| SCHEMBL6668753 | 0.82 | MEN1 (0.46) | POLQMAPTGPBAR1 | |
| SCHEMBL6364178 | 0.82 | ICAM1 (0.38) | POLQMAPTHCRTR1HCRTR2GPBAR1 | |
| SCHEMBL14760908 | 0.81 | MAPT (0.41) | MAPTSCN8ASCN10AHCRTR1HCRTR2 | |
| SCHEMBL1513789 | 0.80 | ERAP1 (0.47) | MAPTERAP1NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1049664-B1 | INHIBITION OF RAF KINASE USING SYMMETRICAL AND UNSYMMETRICAL SUBSTITUTED DIPHENYL UREAS | BAYER PHARMACEUTICALS CORP (US) | 2005-03-16 | — | — | EP | disclosed |
| EP-1049664-A1 | INHIBITION OF RAF KINASE USING SYMMETRICAL AND UNSYMMETRICAL SUBSTITUTED DIPHENYL UREAS | Bayer Corporation (US) | 2000-11-08 | — | — | EP | disclosed |
| WO-1999032436-A1 | INHIBITION OF RAF KINASE USING SYMMETRICAL AND UNSYMMETRICAL SUBSTITUTED DIPHENYL UREAS | BAYER CORPORATION (US) | 1999-07-01 | — | — | WO | disclosed |