Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | LIPE | Q05469 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | CTSA | P10619 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CETP | P11597 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6258541 | 0.87 | SCN8A (0.40) | MAPTKDM4EHCRTR1HCRTR2LMNA | |
| SCHEMBL6249698 | 0.86 | MAPT (0.43) | MAPTKDM4EHPGDHCRTR1HCRTR2 | |
| SCHEMBL6364181 | 0.81 | POLQ (0.41) | MAPTNQO2HCRTR1HCRTR2PTGDR2 | |
| SCHEMBL6959867 | 0.80 | MAPT (0.37) | MAPTNQO2HCRTR1HCRTR2PTGDR2 | |
| SCHEMBL13388895 | 0.79 | MAPT (0.43) | MAPTKDM4EHPGDTP53HCRTR1 | |
| SCHEMBL13388545 | 0.79 | MAPT (0.43) | MAPTKDM4EHPGDNQO2HCRTR1 | |
| SCHEMBL27151678 | 0.78 | MAPT (0.36) | MAPTKDM4EHPGDNQO2HCRTR1 | |
| SCHEMBL1513789 | 0.77 | ERAP1 (0.47) | MAPTNQO2LMNAERAP1SMN1; SMN2 | |
| SCHEMBL6114202 | 0.77 | MAPT (0.43) | MAPTKDM4EHPGDHCRTR1HCRTR2 | |
| SCHEMBL13388542 | 0.75 | MAPT (0.40) | MAPTKDM4EHPGDLIPEHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8816075-B2 | Process for the preparation of dihydroquinazolines | AICURIS GMBH & CO. KG (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20130066073-A1 | PROCESS FOR THE PREPARATION OF DIHYDROQUINAZOLINES | AIC246 AG & CO. KG (DE) | 2013-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130066073-A1 | PROCESS FOR THE PREPARATION OF DIHYDROQUINAZOLINES | QDPR, DHPS, DHX15 | MAPT 2064/4885KDM4E 1466/4885HPGD 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.