Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CXCR2 | P25025 | 15/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6364534 | 0.83 | CXCR2 (0.63) | CXCR2CYP2C9 | |
| SCHEMBL7369831 | 0.80 | APEX1 (0.55) | MEN1KMT2ACXCR2CYP2C9EGFR | |
| SCHEMBL6362563 | 0.79 | CXCR2 (0.72) | CXCR2CYP2C9 | |
| SCHEMBL6364537 | 0.79 | CXCR2 (0.59) | CXCR2CYP2C9 | |
| SCHEMBL6365066 | 0.78 | CXCR2 (0.55) | CXCR2CYP2C9 | |
| SCHEMBL6361796 | 0.78 | CXCR2 (0.55) | CXCR2CYP2C9 | |
| SCHEMBL6362080 | 0.78 | CXCR2 (0.59) | CXCR2CYP2C9 | |
| SCHEMBL6361942 | 0.77 | CXCR2 (0.47) | MEN1KMT2ACXCR2CYP2C9 | |
| SCHEMBL6362470 | 0.76 | CXCR2 (0.55) | CXCR2CYP2C9 | |
| SCHEMBL6361995 | 0.76 | CXCR2 (0.60) | CXCR2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050100902-A1 | 5-cyano-1h-indole derivatives as antagonist of the inerleukine-8 receptors | LABORATORIES FOURNIER S.A. (FR) | 2005-05-12 | — | — | US | disclosed |