Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 1/20 | 0.69 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.69 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL726237 | 0.93 | ABCC9 (0.78) | ABCC9ABCC8KCNJ11ALDH1A1NLRP3 | |
| SCHEMBL726535 | 0.92 | ABCC9 (0.77) | ABCC9ABCC8KCNJ11ALDH1A1NLRP3 | |
| SCHEMBL726534 | 0.92 | ABCC9 (0.77) | ABCC9ABCC8KCNJ11ALDH1A1NLRP3 | |
| SCHEMBL6360174 | 0.92 | ABCC9 (0.56) | ABCC9ABCC8KCNJ11ALDH1A1NLRP3 | |
| SCHEMBL6363472 | 0.90 | ABCC9 (0.66) | ABCC9ABCC8KCNJ11ALDH1A1NLRP3 | |
| SCHEMBL6361002 | 0.89 | ABCC9 (0.70) | ABCC9ABCC8KCNJ11ALDH1A1NLRP3 | |
| SCHEMBL6363889 | 0.89 | ABCC9 (0.69) | ABCC9ABCC8KCNJ11ALDH1A1NLRP3 | |
| SCHEMBL6358933 | 0.88 | ABCC9 (0.69) | ABCC9ABCC8KCNJ11ALDH1A1NLRP3 | |
| SCHEMBL728039 | 0.88 | ABCC9 (0.69) | ABCC9ABCC8KCNJ11ALDH1A1NLRP3 | |
| SCHEMBL6363036 | 0.88 | ABCC9 (0.68) | ABCC9ABCC8KCNJ11ALDH1A1NLRP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1117409-B1 | BENZENESULFONYL(THIO)UREAS IN COMBINATION WITH BETA-BLOCKERS FOR THE TREATMENT OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM | AVENTIS PHARMA GMBH (DE) | 2005-01-26 | — | — | EP | disclosed |
| US-6414030-B1 | 1-((5-(2-(5-TERT-BUTYL-2-METHOXYBENZAMIDO)ETHYL)-2-METHOXYPHEN YL)-SULFONYL)-3-METHYLTHIOUREA AND PROPANOLOL FOR EXAMPLE | AVENTIS PHARMA DEUTSCHLAND, GMBH (DE) | 2002-07-02 | — | — | US | disclosed |
| EP-1117409-A2 | USE OF BENZENESULFONYL(THIO)UREAS FOR THE TREATMENT OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM | Aventis Pharma Deutschland GmbH (DE) | 2001-07-25 | — | — | EP | disclosed |
| WO-2000015204-A2 | USE OF BENZENESULFONYL(THIO)UREAS FOR THE TREATMENT AND PROPHYLAXIS OF DYSFUNCTIONS OF THE AUTONOMOUS NERVOUS SYSTEM AND USE OF BENZENESULFONYL(THIO)UREAS IN COMBINATION WITH BETA-RECEPTOR BLOCKERS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-03-23 | — | — | WO | disclosed |