Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.61 |
| ▸ | PI4KA | P42356 | 1/20 | 0.61 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.61 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.61 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.61 |
| ▸ | CDK1 | P06493 | 11/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 9/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 9/20 | 0.45 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL754049 | 0.87 | ADORA2A (0.60) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL6363839 | 0.84 | ADORA2A (0.58) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL6364195 | 0.81 | ADORA2A (0.54) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL13244955 | 0.79 | CDK2 (0.57) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL6439104 | 0.78 | ADORA1 (0.58) | ADORA2AADORA1CDK1CYP1A2CYP2D6 | |
| SCHEMBL22326756 | 0.77 | CYP1A2 (0.55) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL754007 | 0.76 | ADORA2A (1.00) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL13396186 | 0.76 | ADORA2A (0.48) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| SCHEMBL15387122 | 0.75 | CDK1 (0.57) | ADORA2AADORA2BADORA1PI4KAPI4K2B | |
| Hydrochloric Acid SCHEMBL30881556 | 0.75 | ADORA2A (0.96) | ADORA2AADORA2BADORA1PI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8759510-B2 | Nucleoside cyclicphosphates | GILEAD PHARMASSET LLC (US) | 2014-06-24 | — | — | US | disclosed |
| US-20120258928-A1 | NUCLEOSIDE CYCLICPHOSPHATES | GILEAD PHARMASSET LLC (US) | 2012-10-11 | — | — | US | disclosed |
| US-8173621-B2 | Nucleoside cyclicphosphates | GILEAD PHARMASSET LLC (US) | 2012-05-08 | — | — | US | disclosed |
| US-20100081628-A1 | NUCLEOSIDE CYCLICPHOSPHATES | PHARMASSET, INC. (US) | 2010-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258928-A1 | NUCLEOSIDE CYCLICPHOSPHATES | PNP, NUDT1, TYMP | ADORA2A 102/4885ADORA2B 387/4885ADORA1 163/4885 |
| US-20100081628-A1 | NUCLEOSIDE CYCLICPHOSPHATES | PNP, NUDT1, TYMP | ADORA2A 102/4885ADORA2B 387/4885ADORA1 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.