Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 3/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.34 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL27691425 | 0.98 | ALDH1A1 (0.65) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28210446 | 0.94 | ALDH1A1 (0.60) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1860783 | 0.93 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28280095 | 0.91 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28222336 | 0.91 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL14721111 | 0.91 | ALDH1A1 (0.75) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL8107350 | 0.91 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL1735796 | 0.91 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL10934305 | 0.91 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL6061929 | 0.88 | ALDH1A1 (0.71) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115483421-B | Polyelectrolyte, preparation method and application thereof | 湖北赛傲氢能科技有限公司 | 2024-05-17 | — | — | CN | claimed |
| CN-117356214-A | Rice crab culture soil improvement method | 安徽省农业科学院水产研究所 | 2024-01-09 | — | — | CN | claimed |
| CN-114524466-B | Synthesis method of high-activity catalyst | 无锡东恒新能源科技有限公司 | 2023-04-28 | — | — | CN | claimed |
| EP-0046029-A1 | An application technique for the descaling of surfaces | CENTRAL ELECTRICITY GENERATING BOARD (GB) | 1982-02-17 | — | — | EP | claimed |
| EP-0032416-A2 | Descaling process | CENTRAL ELECTRICITY GENERATING BOARD (GB) | 1981-07-22 | — | — | EP | claimed |
| CN-115483421-B | Polyelectrolyte, preparation method and application thereof | 湖北赛傲氢能科技有限公司 | 2024-05-17 | — | — | CN | disclosed |
| CN-117356214-A | Rice crab culture soil improvement method | 安徽省农业科学院水产研究所 | 2024-01-09 | — | — | CN | disclosed |
| CN-114042459-B | Tree-like soft magnetic Sr 2 FeMoO 6 Preparation method of efficient visible light catalyst | 合肥学院 | 2024-01-05 | — | — | CN | disclosed |
| CN-116722155-A | Anode flow field plate with catalytic activity, preparation method and application | 西安石油大学 | 2023-09-08 | — | — | CN | disclosed |
| CN-114524466-B | Synthesis method of high-activity catalyst | 无锡东恒新能源科技有限公司 | 2023-04-28 | — | — | CN | disclosed |
| CN-114042459-A | Quasi-dendritic soft magnetic Sr2FeMoO6Preparation method of efficient visible light catalyst | 合肥学院 | 2022-02-15 | — | — | CN | disclosed |
| CN-107142503-B | A kind of Fe-Ni-P or Fe-Ni-P-RE amorphous alloy coating and its electro-deposition plating solution and electro-deposition method | 中国科学院金属研究所 | 2019-10-11 | — | — | CN | disclosed |
| EP-0777484-A4 | INTRAVENOUS ALENDRONATE FORMULATIONS | MERCK & CO INC (US) | 1998-08-05 | — | — | EP | disclosed |
| EP-0594564-B1 | DISCOLORATION PREVENTING FOOD PRESERVATIVE AND METHOD | EXTENDED PRODUCT LIFE INC (US) | 1997-07-09 | — | — | EP | disclosed |
| EP-0777484-A1 | INTRAVENOUS ALENDRONATE FORMULATIONS | MERCK & CO. INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005842-A1 | INTRAVENOUS ALENDRONATE FORMULATIONS | MERCK & CO., INC. (US) | 1996-02-29 | — | — | WO | disclosed |
| EP-0594564-A1 | DISCOLORATION PREVENTING FOOD PRESERVATIVE AND METHOD. | AGRA RESEARCH INC (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0594564-A4 | DISCOLORATION PREVENTING FOOD PRESERVATIVE AND METHOD. | AGRA RES INC (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991015959-A1 | DISCOLORATION PREVENTING FOOD PRESERVATIVE AND METHOD | AGRA-RESEARCH, INC. (US) | 1991-10-31 | — | — | WO | disclosed |
| US-4937085-A | CITRIC ACID AND CYSTEINE SOLUTION | AGRA-RESEARCH, INC. (US) | 1990-06-26 | — | — | US | disclosed |