Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 5/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.31 |
| ▸ | EDNRA | P25101 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL636558 | 1.00 | ACMSD (0.38) | ACMSDPKMKDM1AMDM2LMNA | |
| SCHEMBL16966551 | 0.97 | ACMSD (0.37) | ACMSDPKMKDM1AMDM2LMNA | |
| SCHEMBL16966558 | 0.96 | ACMSD (0.37) | ACMSDPKMKDM1AMAPTEDNRA | |
| SCHEMBL6032767 | 0.93 | HCRTR1 (0.37) | ACMSDPKMLMNACYP2D6CYP2C19 | |
| SCHEMBL637328 | 0.93 | HCRTR1 (0.37) | ACMSDPKMLMNACYP2D6CYP2C19 | |
| SCHEMBL4399942 | 0.92 | PDE10A (0.35) | ACMSDPKMLMNACYP2D6CYP2C19 | |
| SCHEMBL636539 | 0.92 | PDE10A (0.35) | ACMSDPKMLMNACYP2D6CYP2C19 | |
| SCHEMBL636242 | 0.91 | ACMSD (0.37) | ACMSDPKMLMNACYP2D6CYP2C19 | |
| SCHEMBL636241 | 0.91 | ACMSD (0.37) | ACMSDPKMLMNACYP2D6CYP2C19 | |
| SCHEMBL4402304 | 0.91 | HIF1A (0.35) | ACMSDPKMLMNACYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119647-B2 | Fused pyrimidineone compounds as TRPV3 modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2012-02-21 | — | — | US | disclosed |