Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.45 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL2585744 | 1.00 | CYP1A2 (0.55) | CYP1A2HSD17B10ALDH1A1HPGDTHRB | |
| Bicarbonate SCHEMBL3836308 | 1.00 | CYP1A2 (0.55) | CYP1A2HSD17B10ALDH1A1HPGDTHRB | |
| Carbamic Acid SCHEMBL15123720 | 0.90 | ALDH1A1 (0.50) | CYP1A2HSD17B10ALDH1A1HPGDTHRB | |
| Carbamic Acid SCHEMBL2581160 | 0.90 | ALDH1A1 (0.50) | CYP1A2HSD17B10ALDH1A1HPGDTHRB | |
| Acetic Acid SCHEMBL28706282 | 0.90 | ALDH1A1 (0.50) | CYP1A2HSD17B10ALDH1A1HPGDTHRB | |
| Carbamic Acid SCHEMBL9232567 | 0.90 | ALDH1A1 (0.50) | CYP1A2HSD17B10ALDH1A1HPGDTHRB | |
| SCHEMBL636521 | 0.90 | CYP1A2 (0.50) | CYP1A2HSD17B10ALDH1A1HPGDTHRB | |
| Acetic Acid SCHEMBL28736368 | 0.90 | ALDH1A1 (0.50) | CYP1A2HSD17B10ALDH1A1HPGDTHRB | |
| SCHEMBL4628576 | 0.90 | CYP1A2 (0.50) | CYP1A2HSD17B10ALDH1A1HPGDTHRB | |
| Acetic Acid SCHEMBL29538855 | 0.90 | ALDH1A1 (0.50) | CYP1A2HSD17B10ALDH1A1HPGDTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 501 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462203-B1 | ELECTRONIC DEVICES COMPRISING MULTI CYCLIC HYDROCARBONS | MERCK PATENT GMBH (DE) | 2016-03-02 | — | — | EP | claimed |
| EP-1128192-B1 | DICHROIC POLARISER AND METHOD FOR MAKING THE SAME | NITTO DENKO CORP (JP) | 2010-01-06 | — | — | EP | claimed |
| EP-1989038-B1 | METHOD FOR PROVIDING A POLARIZING LAYER ON AN OPTICAL ELEMENT | ESSILOR CIE GENERALE D OPTIQUE (FR) | 2009-12-30 | — | — | EP | claimed |
| US-20090187234-A1 | COLORED AND WHITE LIGHT GENERATING LIGHTING DEVICE | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2009-07-23 | — | — | US | claimed |
| US-20090091945-A1 | Coloured Polyurethane Light Guides | POLY OPTICS AUSTRALIA PTY LTD. (AU) | 2009-04-09 | — | — | US | claimed |
| EP-1796189-B1 | Electrode materials having high surface conductivity | HYDRO QUEBEC (CA) | 2009-03-25 | — | — | EP | claimed |
| EP-2038577-A1 | COLORED AND WHITE LIGHT GENERATING LIGHTING DEVICE | Philips Intellectual Property & Standards GmbH (DE) | 2009-03-25 | — | — | EP | claimed |
| EP-1924872-A1 | COLOURED POLYURETHANE LIGHT GUIDES | Poly Optics Australia PTY. Ltd. (AU) | 2008-05-28 | — | — | EP | claimed |
| EP-1049182-B1 | Electrode materials having increased surface conductivity | HYDRO QUEBEC (CA) | 2008-01-02 | — | — | EP | claimed |
| WO-2007141688-A1 | COLORED AND WHITE LIGHT GENERATING LIGHTING DEVICE | PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH (DE) | 2007-12-13 | — | — | WO | claimed |
| EP-0829496-A1 | Pigment preparations | BAYER AG (DE) | 1998-03-18 | — | — | EP | claimed |
| EP-0735109-A2 | Aqueous pigment preparations | BAYER AG (DE) | 1996-10-02 | — | — | EP | claimed |
| EP-0698649-A1 | Use of thermoplastically processible long time stable electroluminescent materials | BASF AKTIENGESELLSCHAFT (DE) | 1996-02-28 | — | — | EP | claimed |
| EP-0403917-B1 | Solid pigment preparations of high concentration | BASF AG (DE) | 1994-02-16 | — | — | EP | claimed |
| EP-0403917-A1 | Solid pigment preparations of high concentration | BASF Aktiengesellschaft (DE) | 1990-12-27 | — | — | EP | claimed |
| EP-0255078-A2 | Aqueous pigment preparations and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-02-03 | — | — | EP | claimed |
| EP-0075182-B1 | CONDITIONING PROCESS OF AN ORGANIC PIGMENT | Mobay Chemical Corporation (US) | 1985-12-11 | — | — | EP | claimed |
| EP-0069895-B1 | PROCESS FOR CONDITIONING A PIGMENT | Mobay Chemical Corporation (US) | 1984-10-10 | — | — | EP | claimed |
| EP-0075182-A1 | Conditioning process of an organic pigment | Mobay Chemical Corporation (US) | 1983-03-30 | — | — | EP | claimed |
| EP-0069895-A2 | Process for conditioning a pigment | Mobay Chemical Corporation (US) | 1983-01-19 | — | — | EP | claimed |