Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MGAM | O43451 | 3/20 | 0.43 |
| ▸ | SI | P14410 | 3/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9453840 | 0.85 | TDP1 (0.56) | ALDH1A1TDP1LMNAMAPTKMT2A | |
| SCHEMBL3400235 | 0.76 | ALDH1A1 (0.59) | ALDH1A1TDP1LMNAL3MBTL1MAPT | |
| SCHEMBL8492249 | 0.75 | GAA (0.46) | ALDH1A1TDP1LMNAMAPTKMT2A | |
| SCHEMBL6016410 | 0.75 | ALDH1A1 (0.49) | ALDH1A1TDP1LMNAL3MBTL1MAPT | |
| SCHEMBL1287837 | 0.74 | ALDH1A1 (0.74) | ALDH1A1TDP1L3MBTL1KMT2ARAB9A | |
| SCHEMBL30535903 | 0.74 | ALDH1A1 (0.74) | ALDH1A1TDP1L3MBTL1KMT2ARAB9A | |
| SCHEMBL29337140 | 0.72 | ALDH1A1 (0.71) | ALDH1A1TDP1L3MBTL1KMT2AGAA | |
| SCHEMBL30987815 | 0.72 | ALDH1A1 (0.71) | ALDH1A1TDP1L3MBTL1KMT2AGAA | |
| Ammonia Solution, Strong SCHEMBL9060371 | 0.72 | ALDH1A1 (0.71) | ALDH1A1TDP1L3MBTL1KMT2AGAA | |
| SCHEMBL5557695 | 0.71 | ALDH1A1 (0.53) | ALDH1A1TDP1LMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884801-B1 | Imidazoline derivatives as alpha-1A adrenoceptor ligands | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| EP-1175406-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066563-A1 | IMIDAZOLINE DERIVATIVES AS ALPHA-1A ADRENOCEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2000-11-09 | — | — | WO | disclosed |
| US-4810282-A | 3-ORTHO-(ISOXAZOLYL,ISOTHIAZOLYL, PYRAZOLYL,THIADIAZOLYL, OXADIAZOLYL AND TRIAZOLYL BENZENESULFONUREYLENE-1,2,4-TRIAZOLES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-03-07 | — | — | US | disclosed |
| EP-0083975-B1 | HERBICIDAL SULFONAMIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-11-19 | — | — | EP | disclosed |
| US-4695311-A | Herbicidal sulfonamides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-09-22 | — | — | US | disclosed |
| US-4606755-A | Herbicidal sulfonamides | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1986-08-19 | — | — | US | disclosed |
| US-4514214-A | Herbicidal sulfamates | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-04-30 | — | — | US | disclosed |
| US-4511392-A | N--/PYRIMIDIN-2-YLAMINOCARBENYL/-HETERO-SUBSTITUETED BENZENSESULFO | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1985-04-16 | — | — | US | disclosed |
| US-4475944-A | PLANT GROWTH REGULATORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-10-09 | — | — | US | disclosed |
| EP-0096593-A2 | Herbicidal sulfamates | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-12-21 | — | — | EP | disclosed |
| EP-0083975-A2 | Herbicidal sulfonamides | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-07-20 | — | — | EP | disclosed |