Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 17/20 | 0.41 |
| ▸ | HTR2B | P41595 | 13/20 | 0.41 |
| ▸ | HTR2A | P28223 | 9/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16569648 | 1.00 | HTR2C (0.41) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL17080568 | 1.00 | HTR2C (0.41) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL6366543 | 1.00 | HTR2C (0.41) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL16569276 | 1.00 | HTR2C (0.41) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL16569446 | 1.00 | HTR2C (0.41) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL2826042 | 0.79 | HTR2C (0.66) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL16585369 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL20570045 | 0.79 | HTR2C (0.66) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL20570046 | 0.79 | HTR2C (0.66) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 | |
| SCHEMBL13591154 | 0.79 | HTR2C (0.63) | HTR2CHTR2BHTR2ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3114126-B1 | 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-10-31 | — | — | EP | disclosed |
| US-10106544-B2 | 1,2-dihydro-3H-pyrrolo[1,2-C]imidazol-3-one derivatives and their use as antibacterial agents | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-10-23 | — | — | US | disclosed |
| EP-3083567-B1 | ANTIBACTERIAL 1H-INDAZOLE AND 1H-INDOLE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-03-07 | — | — | EP | disclosed |
| EP-3044211-B1 | ANTIBACTERIAL 2H-INDAZOLE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-01-03 | — | — | EP | disclosed |
| US-9802901-B2 | Antibacterial 2H-indazole derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-10-31 | — | — | US | disclosed |
| US-20170107223-A1 | 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-04-20 | — | — | US | disclosed |
| US-9624206-B2 | Antibacterial 1H-indazole and 1H-indole derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2017-04-18 | — | — | US | disclosed |
| US-20170029411-A1 | ANTIBACTERIAL 1H-INDAZOLE AND 1H-INDOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2017-02-02 | — | — | US | disclosed |
| US-20160221959-A1 | ANTIBACTERIAL 2H-INDAZOLE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2016-08-04 | — | — | US | disclosed |
| US-20050245529-A1 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160221959-A1 | ANTIBACTERIAL 2H-INDAZOLE DERIVATIVES | H1-3, MRPL21, H1-0 | HTR2C 1128/4885HTR2B 1134/4885HTR2A 2353/4885 |
| US-20170029411-A1 | ANTIBACTERIAL 1H-INDAZOLE AND 1H-INDOLE DERIVATIVES | MRPL21, PYM1, DRD3 | HTR2C 73/4885HTR2B 106/4885HTR2A 111/4885 |
| US-10106544-B2 | 1,2-dihydro-3H-pyrrolo[1,2-C]imidazol-3-one derivatives and their use as antibacterial agents | CCNI, H1-0, H1-3 | HTR2C 2343/4885HTR2B 3339/4885HTR2A 3663/4885 |
| US-20170107223-A1 | 1,2-DIHYDRO-3H-PYRROLO[1,2-C]IMIDAZOL-3-ONE DERIVATIVES AND THEIR USE AS ANTIBACTERIAL AGENTS | CCNI, H1-0, H1-3 | HTR2C 2343/4885HTR2B 3339/4885HTR2A 3663/4885 |
| US-20050245529-A1 | Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds | MCHR1, GPR119, MCHR2 | HTR2C 301/4885HTR2B 250/4885HTR2A 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.