Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.38 |
| ▸ | PDE9A | O76083 | 4/20 | 0.38 |
| ▸ | PNP | P00491 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 6/20 | 0.35 |
| ▸ | PDE1A | P54750 | 2/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17604167 | 0.85 | PRMT5 (0.36) | ADORA2AADORA2BADORA1PNPPDE1C | |
| Hydrochloric Acid SCHEMBL17604355 | 0.84 | PRMT5 (0.35) | ADORA2AADORA2BADORA1PNPPDE1C | |
| SCHEMBL6365300 | 0.83 | ADORA1 (0.41) | ADORA2AADORA2BADORA1PDE1CPDE5A | |
| SCHEMBL6365678 | 0.82 | TSHR (0.39) | ADORA2AADORA2BADORA1PDE9APDE1C | |
| SCHEMBL6366291 | 0.79 | PDE9A (0.46) | ADORA2AADORA2BADORA1PDE9APDE1C | |
| SCHEMBL6366219 | 0.79 | ADORA1 (0.43) | ADORA2AADORA2BADORA1PDE1CPDE5A | |
| SCHEMBL17604244 | 0.78 | ADORA1 (0.35) | ADORA2AADORA2BADORA1PDE9APDE1C | |
| SCHEMBL17604146 | 0.78 | ADORA1 (0.31) | ADORA2AADORA2BADORA1PDE1CPDE5A | |
| SCHEMBL6366662 | 0.76 | PDE9A (0.42) | ADORA2AADORA2BADORA1PDE9APNP | |
| SCHEMBL6367367 | 0.76 | CXCR2 (0.32) | ADORA1PDE1CPDE5APDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6967204-B2 | Treatment of insulin resistance syndrome and type 2 diabetes with PDE9 inhibitors | PFIZER INC (US) | 2005-11-22 | — | — | US | disclosed |
| US-20050070557-A1 | Treatment of insulin resistance syndrome and type 2 diabetes with PDE9 inhibitors | PFIZER INC | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070557-A1 | Treatment of insulin resistance syndrome and type 2 diabetes with PDE9 inhibitors | GPR119, PDE2A, PDE9A | ADORA2A 639/4885ADORA2B 950/4885ADORA1 1339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.