Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGAV | P06756 | 1/20 | 0.40 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6367029 | 0.89 | MEN1 (0.43) | ITGB3ITGA2BMEN1KMT2AHTR2B | |
| SCHEMBL6368243 | 0.83 | ITGB3 (0.57) | ITGB3ITGA2BMEN1KMT2ACASP3 | |
| SCHEMBL6368621 | 0.83 | ITGB3 (0.46) | ITGB3ITGA2BMEN1KMT2AHTR2B | |
| SCHEMBL7774747 | 0.80 | ITGB3 (0.47) | ITGB3ITGA2BMEN1KMT2AHTR2B | |
| SCHEMBL6367424 | 0.80 | ITGB3 (0.61) | ITGB3ITGA2BITGB1ITGAVITGB5 | |
| SCHEMBL7194759 | 0.80 | ITGB3 (0.52) | ITGB3ITGA2BMEN1KMT2AHDAC8 | |
| SCHEMBL6367673 | 0.78 | ITGB3 (0.49) | ITGB3ITGA2BMEN1KMT2ALMNA | |
| SCHEMBL6773935 | 0.77 | ITGB3 (0.52) | ITGB3ITGA2BMEN1KMT2APARP1 | |
| SCHEMBL6777472 | 0.77 | ITGB3 (0.52) | ITGB3ITGA2BMEN1KMT2APARP1 | |
| SCHEMBL6773940 | 0.77 | ITGB3 (0.52) | ITGB3ITGA2BMEN1KMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677308-B1 | INTEGRIN ANTAGONISTS; ANTITUMOR, ANTIMETASTASIS, ANTICARCINOGENIC AGENTS; ANGIOGENESIS AND RESTENOSIS INHIBITORS; OSTEOPOROSIS | G. D. SEARLE & CO. | 2004-01-13 | — | — | US | claimed |
| EP-0889876-B1 | META-SUBSTITUTED PHENYLENE SULPHONAMIDE DERIVATIVES | SEARLE & CO (US) | 2001-07-25 | — | — | EP | claimed |
| EP-0889876-A1 | META-SUBSTITUTED PHENYLENE SULPHONAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036861-A1 | META-SUBSTITUTED PHENYLENE SULPHONAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |
| US-20050176821-A1 | Meta-substituted phenylene sulphonamide derivatives | G. D. SEARLE & CO. (US) | 2005-08-11 | — | — | US | disclosed |
| US-6677308-B1 | INTEGRIN ANTAGONISTS; ANTITUMOR, ANTIMETASTASIS, ANTICARCINOGENIC AGENTS; ANGIOGENESIS AND RESTENOSIS INHIBITORS; OSTEOPOROSIS | G. D. SEARLE & CO. | 2004-01-13 | — | — | US | disclosed |
| EP-0889876-B1 | META-SUBSTITUTED PHENYLENE SULPHONAMIDE DERIVATIVES | SEARLE & CO (US) | 2001-07-25 | — | — | EP | disclosed |
| EP-0889876-A1 | META-SUBSTITUTED PHENYLENE SULPHONAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036861-A1 | META-SUBSTITUTED PHENYLENE SULPHONAMIDE DERIVATIVES | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176821-A1 | Meta-substituted phenylene sulphonamide derivatives | ITGB3, ITGB1, ITGA5 | ITGB3 1/4885ITGA2B 8/4885MEN1 2525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.