Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.60 |
| ▸ | CTSS | P25774 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.50 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.46 |
| ▸ | ACE | P12821 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6368020 | 1.00 | POLB (0.60) | POLBCTSSGAACTSLKMT2A | |
| SCHEMBL7275964 | 0.89 | POLB (0.74) | POLBCTSSGAACTSLKMT2A | |
| SCHEMBL5193787 | 0.89 | POLB (0.74) | POLBCTSSGAACTSLKMT2A | |
| SCHEMBL6795468 | 0.88 | POLB (0.65) | POLBCTSSCTSLKMT2ACTSB | |
| SCHEMBL6375227 | 0.88 | POLB (0.60) | POLBKMT2AFOLH1NAALAD2ALDH1A1 | |
| SCHEMBL6375231 | 0.88 | POLB (0.60) | POLBKMT2AFOLH1NAALAD2ALDH1A1 | |
| SCHEMBL6807325 | 0.85 | POLB (0.61) | POLBCTSSCTSLKMT2ACTSB | |
| SCHEMBL6803415 | 0.85 | BLM (0.56) | POLBCTSSGAACTSLKMT2A | |
| SCHEMBL4421309 | 0.84 | POLB (0.56) | POLBKMT2AFOLH1NAALAD2ALDH1A1 | |
| SCHEMBL4421315 | 0.84 | POLB (0.56) | POLBKMT2AFOLH1NAALAD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903075-B1 | Heterocyclic amide compounds as cell adhesion inhibitors | MERCK & CO., INC. (US) | 2005-06-07 | — | — | US | disclosed |
| US-5776718-A | Reversible protease inhibitors | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-07-07 | — | — | US | disclosed |
| EP-0817778-A1 | REVERSIBLE PROTEASE INHIBITORS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030353-A1 | REVERSIBLE PROTEASE INHIBITORS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-10-03 | — | — | WO | disclosed |