Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arbaclofen Placarbil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 known ✓ | O75899 | 3/20 | 0.34 |
| ▸ | GABBR1 known ✓ | Q9UBS5 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arbaclofen Placarbil SCHEMBL636875 | 1.00 | MAPT (0.39) | MAPTL3MBTL1RAB9ACYP2C9MEN1 | |
| Arbaclofen Placarbil SCHEMBL638830 | 1.00 | MAPT (0.39) | MAPTL3MBTL1RAB9ACYP2C9MEN1 | |
| SCHEMBL3982093 | 0.91 | MAPT (0.39) | MAPTL3MBTL1RAB9ACYP2C9MEN1 | |
| SCHEMBL13101899 | 0.88 | MAPT (0.40) | MAPTL3MBTL1RAB9ACYP2C9MEN1 | |
| Arbaclofen Placarbil SCHEMBL351833 | 0.88 | GABBR2 (0.47) | MAPTL3MBTL1RAB9ACYP2C9MEN1 | |
| Arbaclofen Placarbil SCHEMBL349961 | 0.88 | GABBR2 (0.47) | MAPTL3MBTL1RAB9ACYP2C9MEN1 | |
| Arbaclofen Placarbil SCHEMBL638204 | 0.88 | GABBR2 (0.47) | MAPTL3MBTL1RAB9ACYP2C9MEN1 | |
| Arbaclofen Placarbil SCHEMBL2472988 | 0.88 | GABBR2 (0.47) | MAPTL3MBTL1RAB9ACYP2C9MEN1 | |
| Arbaclofen Placarbil SCHEMBL3375708 | 0.88 | GABBR2 (0.47) | MAPTL3MBTL1RAB9ACYP2C9MEN1 | |
| Arbaclofen Placarbil SCHEMBL14689524 | 0.87 | GABBR2 (0.46) | MAPTL3MBTL1RAB9ACYP2C9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660440-B1 | ACYLOXYALKYL CARBAMATE PRODRUGS, METHODS OF SYNTHESIS AND USE | XENOPORT INC (US) | 2012-02-22 | — | — | EP | claimed |