Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 5/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | PRKDC | P78527 | 4/20 | 0.52 |
| ▸ | NME2 | P22392 | 1/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033351 | 0.90 | NCF1 (0.61) | NCF1HSD17B10ADRB2ADRB1MAPT | |
| SCHEMBL5037448 | 0.89 | NCF1 (0.63) | NCF1HSD17B10ADRB2ADRB1KDM4E | |
| Hydrochloric Acid SCHEMBL5040456 | 0.88 | NCF1 (0.62) | NCF1HSD17B10ADRB2ADRB1KDM4E | |
| SCHEMBL5036322 | 0.87 | PRKDC (0.55) | NCF1HSD17B10PRKDCMETTL3KDM4E | |
| Hydrochloric Acid SCHEMBL5035842 | 0.86 | PRKDC (0.55) | NCF1HSD17B10PRKDCMETTL3KDM4E | |
| SCHEMBL5037488 | 0.83 | NCF1 (0.48) | NCF1HSD17B10PRKDCMETTL3KDM4E | |
| Hydrochloric Acid SCHEMBL5035748 | 0.82 | NCF1 (0.47) | NCF1HSD17B10PRKDCMETTL3KDM4E | |
| SCHEMBL5036125 | 0.81 | NCF1 (0.45) | NCF1ADRB2ADRB1MAPTALDH1A1 | |
| SCHEMBL5033338 | 0.81 | NCF1 (0.45) | NCF1ADRB2ADRB1MAPTALDH1A1 | |
| SCHEMBL5033346 | 0.81 | NCF1 (0.45) | NCF1ADRB2ADRB1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100376557-C | Quinoline derivatives as ligands for neuropeptide Y receptors | HOFFMANN LA ROCHE (CH) | 2008-03-26 | — | — | CN | disclosed |
| US-20050049413-A1 | Quinoline derivatives | MUELLER WERNER (CH) | 2005-03-03 | — | — | US | disclosed |
| US-6818767-B2 | NEUROPEPTIDE Y (NPY) ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF ARTHRITIS, CARDIOVASCULAR DISEASES, DIABETES, RENAL FAILURE, EATING DISORDERS, OR OBESITY | HOFFMANN-LA ROCHE INC. | 2004-11-16 | — | — | US | disclosed |
| CN-1522249-A | Quinoline derivatives as ligands for neuropeptide Y receptors | — | 2004-08-18 | — | — | CN | disclosed |
| US-20020198194-A1 | Quinoline derivatives | HOFFMANN-LA ROCHE INC. | 2002-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020198194-A1 | Quinoline derivatives | NPY2R, NPY1R, NPY4R | NCF1 1052/4885HSD17B10 3906/4885PRKDC 4750/4885 |
| US-20050049413-A1 | Quinoline derivatives | NPY2R, NPY1R, NPY4R | NCF1 1052/4885HSD17B10 3906/4885PRKDC 4750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.