Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.81 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.81 |
| ▸ | HPGD | P15428 | 1/20 | 0.81 |
| ▸ | HTT | P42858 | 1/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.49 |
| ▸ | BCL6 | P41182 | 2/20 | 0.49 |
| ▸ | CDK2 | P24941 | 6/20 | 0.47 |
| ▸ | CDK1 | P06493 | 5/20 | 0.47 |
| ▸ | CDK4 | P11802 | 3/20 | 0.47 |
| ▸ | CCND1 | P24385 | 3/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.46 |
| ▸ | CCND3 | P30281 | 1/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314537 | 0.95 | EGFR (0.75) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8318350 | 0.90 | EGFR (0.71) | EGFRERBB2HPGDHTTMAPT | |
| Falnidamol SCHEMBL29387986 | 0.89 | EGFR (1.00) | EGFRERBB2HPGDHTTMAPT | |
| Falnidamol SCHEMBL158563 | 0.89 | EGFR (1.00) | EGFRERBB2HPGDHTTMAPT | |
| Falnidamol SCHEMBL29403789 | 0.89 | EGFR (0.98) | EGFRERBB2HPGDHTTMAPT | |
| Falnidamol SCHEMBL29409569 | 0.89 | EGFR (0.98) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8314263 | 0.88 | EGFR (0.84) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8312687 | 0.88 | EGFR (0.75) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8312684 | 0.88 | EGFR (0.75) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8487889 | 0.86 | EGFR (0.70) | EGFRERBB2HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2419110-A1 | METHODS OF TREATING CANCERS WITH HER3 ANTISENSE OLIGONUCLEOTIDES | Enzon Pharmaceuticals, Inc. (US) | 2012-02-22 | — | — | EP | disclosed |
| WO-2010120861-A1 | METHODS OF TREATING CANCERS WITH HER3 ANTISENSE OLIGONUCLEOTIDES | ENZON PHARMACEUTICALS, INC. (US) | 2010-10-21 | — | — | WO | disclosed |