Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.75 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.75 |
| ▸ | HTT | P42858 | 1/20 | 0.75 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | BCL6 | P41182 | 2/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312687 | 1.00 | EGFR (0.75) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8316960 | 0.92 | EGFR (0.62) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8316956 | 0.92 | EGFR (0.62) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8314263 | 0.92 | EGFR (0.84) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6995190 | 0.89 | EGFR (0.80) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL7578649 | 0.89 | EGFR (0.69) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL7578640 | 0.89 | EGFR (0.69) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL6993354 | 0.88 | EGFR (0.68) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL637276 | 0.88 | EGFR (0.81) | EGFRERBB2HPGDHTTCSNK2A1 | |
| SCHEMBL8319701 | 0.87 | EGFR (0.56) | EGFRERBB2HPGDHTTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |