Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | HTR6 | P50406 | 1/20 | 0.65 |
| ▸ | ESR1 | P03372 | 12/20 | 0.64 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.64 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.64 |
| ▸ | ESRRG | P62508 | 14/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ESRRB | O95718 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6373608 | 1.00 | LMNA (0.65) | LMNAHTR6ESR1CYP19A1ESR2 | |
| SCHEMBL6373600 | 1.00 | LMNA (0.65) | LMNAHTR6ESR1CYP19A1ESR2 | |
| SCHEMBL5739852 | 0.95 | LMNA (0.56) | LMNAHTR6ESR1CYP19A1ESR2 | |
| SCHEMBL5737939 | 0.95 | LMNA (0.71) | LMNAHTR6ESR1CYP19A1ESR2 | |
| Ospemifene SCHEMBL948120 | 0.95 | LMNA (0.71) | LMNAHTR6ESR1CYP19A1ESR2 | |
| Ospemifene SCHEMBL2231997 | 0.95 | LMNA (0.71) | LMNAHTR6ESR1CYP19A1ESR2 | |
| Ospemifene SCHEMBL948118 | 0.95 | LMNA (0.71) | LMNAHTR6ESR1CYP19A1ESR2 | |
| SCHEMBL5739854 | 0.95 | LMNA (0.56) | LMNAHTR6ESR1CYP19A1ESR2 | |
| SCHEMBL5739858 | 0.95 | LMNA (0.56) | LMNAHTR6ESR1CYP19A1ESR2 | |
| SCHEMBL5738281 | 0.90 | ESR1 (0.79) | LMNAHTR6ESR1CYP19A1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6875775-B2 | Triphenylalkene derivatives and their use as selective estrogen receptor modulators | HORMOS MEDICAL OY LTD (FI) | 2005-04-05 | — | — | US | disclosed |
| US-6576645-B1 | Such as 3-(4-chloro-1-(4-(2-(2-hydroxyethoxy)ethoxy)phenyl)--2-phenylbut-1 -enyl)phenol; producing tissue specific estro-genic and/or antiestrogenic effect | HORMOS MEDICAL OY LTD (FI) | 2003-06-10 | — | — | US | disclosed |