Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | BRD4 | O60885 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29410988 | 0.90 | NAAA (0.56) | NAMPTRAB9ABRD4HDAC1HDAC6 | |
| SCHEMBL10612987 | 0.84 | HDAC1 (0.52) | NAMPTRAB9ABRD4KMT2AHDAC1 | |
| SCHEMBL29004722 | 0.80 | KMT2A (0.47) | NAMPTRAB9AKMT2AHDAC1HDAC6 | |
| SCHEMBL11726168 | 0.80 | NAMPT (0.53) | NAMPTRAB9AHDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL9772620 | 0.79 | NAMPT (0.59) | NAMPTRAB9AKMT2AHDAC1EPHX2 | |
| SCHEMBL3707443 | 0.79 | NAMPT (1.00) | NAMPT | |
| SCHEMBL29531015 | 0.78 | NAMPT (0.54) | NAMPTKMT2AHDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL27176270 | 0.77 | KMT2A (0.62) | RAB9AKMT2AHDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL27176255 | 0.76 | NAMPT (0.47) | NAMPTRAB9AKMT2AHDAC1HDAC6 | |
| SCHEMBL27176232 | 0.76 | KMT2A (0.47) | NAMPTRAB9AKMT2AHDAC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144393-A1 | 2-SUBSTITUTED 5-(PHENYL)-1,2-DIHYDRO-3H-3-BENZAZEPINE-3-CARBOXAMIDE DERIVATIVES AS BRD4 INHIBITORS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-08-31 | — | — | WO | disclosed |
| EP-2420142-A1 | Use of N-2-(pyrazolyl)ethylphenylcarboxamides or their salts for controlling powdery mildew primary infections | Bayer CropScience AG (DE) | 2012-02-22 | — | — | EP | disclosed |
| EP-2420142-A1 | Use of N-2-(pyrazolyl)ethylphenylcarboxamides or their salts for controlling powdery mildew primary infections | Bayer CropScience AG (DE) | 2012-02-22 | — | — | EP | disclosed |