Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 10/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29742732 | 0.75 | KDM4E (0.59) | KDM4EHPGDHSD17B10ALDH1A1GLA | |
| SCHEMBL970053 | 0.75 | KDM4E (0.59) | KDM4EHPGDHSD17B10ALDH1A1GLA | |
| SCHEMBL11265444 | 0.71 | GABRA5 (0.50) | GABRA5GABRA1CHEK1CHEK2CDK1 | |
| SCHEMBL11265442 | 0.70 | KDM4E (0.44) | CHEK1KDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL10681757 | 0.69 | GABRA5 (0.36) | GABRA5GABRA1KDM4EHPGDHSD17B10 | |
| SCHEMBL3356849 | 0.69 | GABRA5 (0.50) | GABRA5GABRA1TDO2IDO1 | |
| SCHEMBL5995444 | 0.67 | KDM4E (0.53) | GABRA5GABRA1KDM4EHPGDHSD17B10 | |
| SCHEMBL10514072 | 0.67 | HTT (0.56) | ALDH1A1 | |
| SCHEMBL5274622 | 0.67 | NQO2 (0.41) | KDM4CKDM4EHPGDHSD17B10ALDH1A1 | |
| SCHEMBL31515495 | 0.67 | PARP1 (0.48) | GABRA5CHEK1CHEK2CDK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050009733-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage | PHARMACIA CORPORATION | 2005-01-13 | — | — | US | disclosed |
| EP-0285837-A1 | Imidazodiazepin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-10-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009733-A1 | Compositions of a cyclooxygenase-2 selective inhibitor and a potassium ion channel modulator for the treatment of central nervous system damage | KCNJ2, KCNN2, KCNK2 | GABRA5 787/4885CYP11B2 1003/4885KDM4C 2062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.